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1- University of Maiduguri
2- Cyprus International University , Marthaorendua@unimaid.edu.ng
2- Cyprus International University , Marthaorendua@unimaid.edu.ng
Abstract: (20 Views)
Introduction: Fenugreek has a long history as both a culinary and medicinal herb in the ancient world and in the current study, the authors attempted to determine the effect of this plant on diclofenac-induced hepatic, renal and duodenal damage.
Methodology:Thirty Five (35) albino rats were randomly divided into five groups comprising of seven (7) rats each. Fenugreek seed extract (TFG) was administered to the rats in groups III and IV via the orogastric route. Diclofenac (50mg/kg) was also administered by the oral route to the rats in groups II, III, IV and V to induce hepatotoxicity and nephrotoxicity. 500mg/kg Livofloxacin (LVF) was administered as treatment too rats in group V. Twenty four hours after the last dose, all animals were sacrificed and organs of interest removed for histopathological study.
Results: TGF increased the weight of kidney and liver tissue relative to total body weight, maintained the histology of the kidney tissues at a concentration of 500mg/kg and 1000mg/kg, ameliorated the damage observed in the intestinal mucosa following administration of diclofenac and mitigated hepatocyte damage, interhepatocytic hemorrhage,vascular congestion and restored arrangement of hepatocytes.
Conclusion: The findings of the current study demonstrate that TGF exhibited promising therapeutic effects by significantly prevented diabetic toxicity in the duodenum, liver and kidney by ameliorating diclofenac-induced damage
Methodology:Thirty Five (35) albino rats were randomly divided into five groups comprising of seven (7) rats each. Fenugreek seed extract (TFG) was administered to the rats in groups III and IV via the orogastric route. Diclofenac (50mg/kg) was also administered by the oral route to the rats in groups II, III, IV and V to induce hepatotoxicity and nephrotoxicity. 500mg/kg Livofloxacin (LVF) was administered as treatment too rats in group V. Twenty four hours after the last dose, all animals were sacrificed and organs of interest removed for histopathological study.
Results: TGF increased the weight of kidney and liver tissue relative to total body weight, maintained the histology of the kidney tissues at a concentration of 500mg/kg and 1000mg/kg, ameliorated the damage observed in the intestinal mucosa following administration of diclofenac and mitigated hepatocyte damage, interhepatocytic hemorrhage,vascular congestion and restored arrangement of hepatocytes.
Conclusion: The findings of the current study demonstrate that TGF exhibited promising therapeutic effects by significantly prevented diabetic toxicity in the duodenum, liver and kidney by ameliorating diclofenac-induced damage
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Publisher Tel: 021 4535 5555, 021 4535 5000
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
