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Volume 11, Issue 1 (January-Fabruary 2017)
IJT 2017, 11(1): 55-58 |
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Sulyman A O, Akolade J O, Na’Allah A, Aladodo R A, Jamiu H O. Effect of Administration of Root Ethanolic Extract of Aristolochia Ringens on the Liver Functional Indices of Male Wistar Rats. IJT 2017; 11 (1) :55-58
URL: http://ijt.arakmu.ac.ir/article-1-535-en.html
URL: http://ijt.arakmu.ac.ir/article-1-535-en.html
Abdulhakeem Olarewaju Sulyman * 
1, Jubril Olayinka Akolade2 , Asiat Na’Allah3 , Raliat Abimbola Aladodo4 , Habeeb Olasunkanmi Jamiu4
1, Jubril Olayinka Akolade2 , Asiat Na’Allah3 , Raliat Abimbola Aladodo4 , Habeeb Olasunkanmi Jamiu4
1- Department of Biosciences and Biotechnology (Biochemistry Unit), Kwara State University, Malete, Ilorin, Nigeria. , abdulhakeem.sulyman@kwasu.edu.ng
2- MSc of Biochemistry, Biotechnology and Genetic Engineering Advanced Laboratory, Sheda Science and Technology Complex, Sheda, Abuja, Nigeria.
3- Department of Biological Sciences (Biochemistry Unit) Al-Hikmah University, Ilorin, Nigeria.
4- Department of Biosciences and Biotechnology (Biochemistry Unit), Kwara State University, Malete, Ilorin, Nigeria.
2- MSc of Biochemistry, Biotechnology and Genetic Engineering Advanced Laboratory, Sheda Science and Technology Complex, Sheda, Abuja, Nigeria.
3- Department of Biological Sciences (Biochemistry Unit) Al-Hikmah University, Ilorin, Nigeria.
4- Department of Biosciences and Biotechnology (Biochemistry Unit), Kwara State University, Malete, Ilorin, Nigeria.
Abstract: (4313 Views)
Background: The alcoholic decoction of root ethanolic extract of Aristolochia ringens is taken orally to treat various ailments in South-west Nigeria without prior knowledge of its potential toxic effect. Therefore, this study aimed at assessing the toxicity potentials of root ethanolic extract of A. ringens on functional indices and histology of the liver.
Methods: Twenty male rats were randomized into four groups of five animals each. Group A (control) received 0.5 ml of distilled water, group B, C and D received 75, 150 and 300 mg/kg b. wt. of the extract respectively. The administration was done orally and lasted for fourteen days.
Results: The extract significantly reduced the activities of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT) as well as reduction in the level of serum albumin and direct bilirubin (P<0.05) while the level of total bilirubin increased. The activities of these enzymes i.e. ALP, ALT and AST increased in the serum at all the doses investigated.
Conclusion: Ethanolic extract from A. ringens root may not be completely safe when administered repeatedly.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
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