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Volume 13, Issue 1 (January 2019)
IJT 2019, 13(1): 41-44 |
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Sobhani B, Roomiani S, Ahmadi Z, Ashrafizadeh M. Histopathological Analysis of Testis: Effects of Astaxanthin Treatment against Nicotine Toxicity. IJT 2019; 13 (1) :41-44
URL: http://ijt.arakmu.ac.ir/article-1-723-en.html
URL: http://ijt.arakmu.ac.ir/article-1-723-en.html
1- PhD student of Veterinary Medicine, Ferdowsi University of Mashhad. Mashhad, Iran.
2- Department of Basic Science, Faculty of Veterinary Medicine, University of Shushtar. Khuzestan, Iran.
3- Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz. Tabriz, Iran.
2- Department of Basic Science, Faculty of Veterinary Medicine, University of Shushtar. Khuzestan, Iran.
3- Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz. Tabriz, Iran.
Abstract: (4419 Views)
Background: Nicotine is a toxic compound in the cigarette smoke and has destructive effects on various human organs. Astaxanthin is a carotenoid with high antioxidant property. In this study, we investigated the protective effects of astaxanthin against nicotine-induced toxicity in mice testes.
Methods: Forty-two inbred balb/c male mice were divided into six groups:Group 1, received 1 ml normal saline daily; Group 2, received nicotine (1.5mg/kg); Group 3, received astaxanthin (25mg/kg); Group 4, received astaxanthin (50mg/kg); Group 5, received astaxanthin (25mg/kg) plus nicotine (1.5mg/kg); and group 6, received astaxanthin (50mg/kg) plus nicotine (1.5mg/kg). After collecting testes samples, microscopic slides were prepared at the School of Veterinary Medicine, University of Mashhad, and the prepared slides were examined under light microscopy.
Results: The histological structures of the testes were normal in the control group and those receiving astaxanthin, regardless of nicotine (groups 3, 4, 5 & 6). However, group 2 that received only nicotine, showed transformed testicular histology with severe hemorrhage.
Conclusion: Based on the results, nicotine caused harmful effects on the mice testes and astaxanthin appeared to protect the organs against the toxic effects of nicotine.
Methods: Forty-two inbred balb/c male mice were divided into six groups:Group 1, received 1 ml normal saline daily; Group 2, received nicotine (1.5mg/kg); Group 3, received astaxanthin (25mg/kg); Group 4, received astaxanthin (50mg/kg); Group 5, received astaxanthin (25mg/kg) plus nicotine (1.5mg/kg); and group 6, received astaxanthin (50mg/kg) plus nicotine (1.5mg/kg). After collecting testes samples, microscopic slides were prepared at the School of Veterinary Medicine, University of Mashhad, and the prepared slides were examined under light microscopy.
Results: The histological structures of the testes were normal in the control group and those receiving astaxanthin, regardless of nicotine (groups 3, 4, 5 & 6). However, group 2 that received only nicotine, showed transformed testicular histology with severe hemorrhage.
Conclusion: Based on the results, nicotine caused harmful effects on the mice testes and astaxanthin appeared to protect the organs against the toxic effects of nicotine.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
