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:: Volume 5, Number 15 (Winter 2012) ::
IJT 2012, 5(15): 558-564 Back to browse issues page
The Cytotoxic and Synergistic Effects of Flavonoid Derivatives on Doxorubicin Cytotoxicity in Hela, MDA-MB-231, and HT-29 Cancer Cells
Hojjat Sadeghi-Aliabadi *, Hossein Mosavi, Mina Mirian, Saeed Kakhki, Afshin Zarghi
School of Pharmacy and Pharmaceutical Sciences, Isfahan, Iran. , sadeghi@pharm.mui.ac.ir
Abstract:   (10536 Views)
Background: Flavonoids have a variety of biological activities, such as anti-allergic, anti-inflammatory, anti-oxidative, free radical scavenging, and anti-mutagenic.
Methods: The cytotoxic effects of three synthesized flavonoid derivatives (K3, K4 and K5) were evaluated against Hela , MDA-MB -231 and HT-29 cancer cells using MTT assay.
Results: The results showed that these flavonoids were not cytotoxic at any tested concentrations (0.1, 0.05, 0.01, and 0.001 mM). To evaluate the possible synergistic effect of synthetic flavonoids with chemotherapeutic agent, the compound (K4) was examined against Hela and MDA-MB-231 cells in combination with different concentrations of doxorubicin (0.01 and 0.001mM). This combination treatment significantly increased the cytotoxicity of doxorubicin (P < 0.05).
Conclusion: Synthesized flavonoids could be used either in combination therapy with other chemotherapeutic agents or used as antioxidants in food supplements.
Keywords: Hela, HT-29, MDA-MB-231, MTT Assay, Synergism, Synthetic Flavonoid.
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Type of Study: Research | Subject: General
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Sadeghi-Aliabadi H, Mosavi H, Mirian M, Kakhki S, Zarghi A. The Cytotoxic and Synergistic Effects of Flavonoid Derivatives on Doxorubicin Cytotoxicity in Hela, MDA-MB-231, and HT-29 Cancer Cells. IJT. 2012; 5 (15) :558-564
URL: http://ijt.arakmu.ac.ir/article-1-109-en.html
Volume 5, Number 15 (Winter 2012) Back to browse issues page
مجله سم شناسی و مسمومیتهای ایران Iranian Journal of Toxicology
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