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Volume 17, Issue 4 (In Press 2023)
IJT 2023, 17(4): 0-0 |
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Mahmoud Ashry M A. The Antioxidant and Anti-inflammatory of Lactoferrin Nanomaterial on Aflatoxin B1-Induced Hepatotoxicity in Male Rats. IJT 2023; 17 (4)
URL: http://ijt.arakmu.ac.ir/article-1-1243-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1243-en.html
Faculty of Science, Al-Azhar University, Assuit, Egypt , mahmoud_ashry20@yahoo.com
Abstract: (110 Views)
Background: Aflatoxin B1 (AFB1), one of the main types of aflatoxins, is the most dangerous and prevalent. Due to its liver-damaging properties, AFB1 has been linked to an increased risk of hepatocellular carcinoma. This study's goal was to assess how lactoferrin (LF NPs) protected rats' livers from hepatotoxicity caused by aflatoxin B1 by acting as an antioxidant and an anti-inflammatory.
Methods: Adult male Wistar rats (weighing between 140 and 200 g) were separated into four groups, each with ten rats: 1) A group of healthy individuals; 2) healthy rats treated ip with PEE (50 mg/kg/day); 3) rats given Aflatoxin B1 (40 mg/kg/day) orally for six weeks; 4) animals post-injected with LF NPs for six weeks after being intoxicated with AFB1.
Results: The results showed that LF NPs were successful in reducing AFB1-induced hepatotoxicity after six weeks of treatment; this was demonstrated by a significant decline in serum ALAT, ASAT, GGT, ALP, TNF-, IL-1, CD4 and AFP values as well as hepatic MDA, NO, and DNA fragmentation along with a significant increase in serum total protein and albumin levels as well as hepatic GSH, SOD, and CAT values; These effects agonized the structural restoration of the histological picture of the liver.
Conclusion: It is possible to draw the conclusion that LF NPs have been highly effective in reducing the oxidative stress caused by AFB1 and protecting the liver from its harmful effects. LF NPs may be thought of as an exciting supplement candidate for safeguarding the liver from an adverse effect of AFB1.
Methods: Adult male Wistar rats (weighing between 140 and 200 g) were separated into four groups, each with ten rats: 1) A group of healthy individuals; 2) healthy rats treated ip with PEE (50 mg/kg/day); 3) rats given Aflatoxin B1 (40 mg/kg/day) orally for six weeks; 4) animals post-injected with LF NPs for six weeks after being intoxicated with AFB1.
Results: The results showed that LF NPs were successful in reducing AFB1-induced hepatotoxicity after six weeks of treatment; this was demonstrated by a significant decline in serum ALAT, ASAT, GGT, ALP, TNF-, IL-1, CD4 and AFP values as well as hepatic MDA, NO, and DNA fragmentation along with a significant increase in serum total protein and albumin levels as well as hepatic GSH, SOD, and CAT values; These effects agonized the structural restoration of the histological picture of the liver.
Conclusion: It is possible to draw the conclusion that LF NPs have been highly effective in reducing the oxidative stress caused by AFB1 and protecting the liver from its harmful effects. LF NPs may be thought of as an exciting supplement candidate for safeguarding the liver from an adverse effect of AFB1.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
