Neuroprotective effect of ethylacetate fraction of Antiaris africana against sodium azide induced neurotoxicity in the striatum of male wistar rats

Ilesanmi, Omotayo; Inala, Mercy; Ridwan, Abiodun

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Ilesanmi O, Inala M, Ridwan A. Neuroprotective effect of ethylacetate fraction of Antiaris africana against sodium azide induced neurotoxicity in the striatum of male wistar rats. IJT 2023; 17 (4)
URL: http://ijt.arakmu.ac.ir/article-1-1244-en.html

Neuroprotective effect of ethylacetate fraction of Antiaris africana against sodium azide induced neurotoxicity in the striatum of male wistar rats

Omotayo Ilesanmi ^*

¹, Mercy Inala²

, Abiodun Ridwan³

1- Federal University Otuoke, Nigeria , ilesanmiob@fuotuoke.edu.ng
2- Federal University Otuoke
3- University of Lagos

Abstract: (80 Views)

Antiaris africana has been discovered to protect against several neurotoxicants. This research investigated the neuroprotective effect of the ethylacetate fraction of A. africana (EFA) against sodium azide (NaN3). The striatum from the brain of male Wistar rats was incubated with varying concentrations of EFA in the presence of NaN3. The protective effect of EFA was accessed by measuring the concentration and activities of different mitochondria respiratory enzymes (NADH cytochrome C reductase, NADH succinate dehydrogenase, succinate cytochrome C reductase), neurotransmitters (acetylcholinesterase), reduced glutathione, malondialdehyde, protein carbonyl, and lactate dehydrogenase. The results show that NaN3 inhibits the activities of the MRE as compared to the control (P<0.05), releases lactate dehydrogenase from the striatum, increases the activity of acetylcholinesterase, caused oxidative stress, and increased monoamine oxidase activity as compared to the control (P<0.05). all the observed toxic effect of NaN3 was prevented by all the administered concentration of EFA. In conclusion, this report contributed to the efficacy of Antiaris africana in preventing the damaging effect of chemicals on brain cells.

Keywords: Antiaris africana, flavonoid, sodium azide, striatum, neurotoxicity

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Type of Study: Research | Subject: General

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