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Volume 17, Issue 4 (In Press 2023)
IJT 2023, 17(4): 0-0 |
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Oluranti O, Akin-Aborishade P, Olarinde A, Alabi B, Ojo-Ayangoke E, Mayowa T, et al . The Role of Rutin on Hepato-Renal Toxicity, Redox Status and Lipid Profile in Bisphenol-A and Dibutyl Phtalate Co-Exposure. IJT 2023; 17 (4)
URL: http://ijt.arakmu.ac.ir/article-1-1259-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1259-en.html
Olufemi Oluranti * 
1, Praise Akin-Aborishade2 , Atilola Olarinde2 , Babatunde Alabi3 , Esther Ojo-Ayangoke2 , Timilehin Mayowa2 , Marvelous Paseda2 , Ayomide Lawal2 , Ibukun Dahunsi2
1, Praise Akin-Aborishade2 , Atilola Olarinde2 , Babatunde Alabi3 , Esther Ojo-Ayangoke2 , Timilehin Mayowa2 , Marvelous Paseda2 , Ayomide Lawal2 , Ibukun Dahunsi2
1- Department of Physiology, College of Health Sciences, Bowen University, P.M.B. 284, Iwo, Nigeria , olufemi2008@gmail.com
2- Department of Physiology, College of Health Sciences, Bowen University, P.M.B. 284, Iwo, Nigeria
3- Department of Pharmacology and Therapeutics, College of Health Sciences, Bowen University, P.M.B. 284, Iwo, Nigeria
2- Department of Physiology, College of Health Sciences, Bowen University, P.M.B. 284, Iwo, Nigeria
3- Department of Pharmacology and Therapeutics, College of Health Sciences, Bowen University, P.M.B. 284, Iwo, Nigeria
Abstract: (66 Views)
Background: Environmental pollutants, such as plastic-derived substances Bisphenol-A (BPA) and Di-butyl phthalate (DBP), have been linked to an increase in the occurrence of human health hazard including lipid dysmetabolism and organ toxicity. This study was designed to investigate the hepato-renal toxic effect of plasticizers and the possible intervention role of rutin in rat.
Materials and Methods: Eighteen rats were randomized into 3 groups of 6 animals each and were treated as follows for 28 days: Control (0.1% DMSO), Bisphenol-A and Dibutyl phthalate (BPA 25 mg/kg + DBP 25 mg/kg, p.o), Bisphenol-A, Dibutyl phthalate and rutin (BPA 25 mg/kg + DBP 25 mg/kg + Rt 50 mg/kg, p.o). Hepatic and renal toxic biomarkers, redox status and lipid profile were measured.
Results: The plasticizers toxicity led to increase in GGT, urea, renal MDA and significant reduction in SOD and CAT activities relative to control. Total cholesterol and low-density lipoprotein (LDL) levels in the plasma increased. Hepatic total cholesterol, LDL, FFA, TG levels increased and HDL decreased while total cholesterol, TG and LDL levels increased in the kidney. However, these alterations were ameliorated by rutin in the plasticizers-treated rats.
Conclusion: Flavonoid, rutin demonstrated hepato-renal protective effect against the assaults from plasticizers exposure.
Materials and Methods: Eighteen rats were randomized into 3 groups of 6 animals each and were treated as follows for 28 days: Control (0.1% DMSO), Bisphenol-A and Dibutyl phthalate (BPA 25 mg/kg + DBP 25 mg/kg, p.o), Bisphenol-A, Dibutyl phthalate and rutin (BPA 25 mg/kg + DBP 25 mg/kg + Rt 50 mg/kg, p.o). Hepatic and renal toxic biomarkers, redox status and lipid profile were measured.
Results: The plasticizers toxicity led to increase in GGT, urea, renal MDA and significant reduction in SOD and CAT activities relative to control. Total cholesterol and low-density lipoprotein (LDL) levels in the plasma increased. Hepatic total cholesterol, LDL, FFA, TG levels increased and HDL decreased while total cholesterol, TG and LDL levels increased in the kidney. However, these alterations were ameliorated by rutin in the plasticizers-treated rats.
Conclusion: Flavonoid, rutin demonstrated hepato-renal protective effect against the assaults from plasticizers exposure.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
