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Volume 18, Issue 3 (July 2024)
IJT 2024, 18(3): 120-129 |
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Ethics code: REL/FOS/22/04
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Kpomah B, Kpomah E D, Ugbune U, Odafe Agbaire P, Apiamu A. Reduced Toxicity of Methylphenyl Ketone Compounds by Combining them with Metal Ions. IJT 2024; 18 (3) :120-129
URL: http://ijt.arakmu.ac.ir/article-1-1312-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1312-en.html
Bridget Kpomah1 
, Enyohwo Dennis Kpomah * 2, Ufuoma Ugbune3 , Patience Odafe Agbaire4 , Augustine Apiamu5
, Enyohwo Dennis Kpomah * 2, Ufuoma Ugbune3 , Patience Odafe Agbaire4 , Augustine Apiamu5
1- PhD, Chemistry Department, Delta State University, Abraka, Nigeria.
2- PhD, Biochemistry Department, Federal University Otuoke, Bayelsa State, Nigeria. ,tressurekpomah@yahoo.com
3- PhD, Chemical Sciences Department, Delta State University of Science and Technology, Ozoro, Nigeria.
4- Professor, Chemistry Department, Delta State University, Abraka, Nigeria.
5- PhD, Biochemistry Department, Delta State University Abraka, Nigeria.
2- PhD, Biochemistry Department, Federal University Otuoke, Bayelsa State, Nigeria. ,
3- PhD, Chemical Sciences Department, Delta State University of Science and Technology, Ozoro, Nigeria.
4- Professor, Chemistry Department, Delta State University, Abraka, Nigeria.
5- PhD, Biochemistry Department, Delta State University Abraka, Nigeria.
Abstract: (155 Views)
Background: The human race is currently burdened with cases of multi-drug-resistant pathogenic microorganisms, causing a menace to the efficacy of the existing antimicrobials. This has created a critical need for innovative drugs with minimal toxicity. The present study aimed to assess the sub-chronic toxicity of some transition metal complexes containing Schiff base ligand with 2,2-bipyridine.
Methods: A total of 36 male rats weighing 178.12±5.48 g were assigned to six groups of six per group. Group A: administered 5% DMSO; Group B: treated with 200 mg kg-1 BW of 2, 2-Bipyridine; Group C: treated with 200 mg kg-1 BW MPK-TSC; Group D: treated with 200 mg kg-1 body weight [Cu (MPK-TSC) (Bipy)Cl2]; Group E: treated with 200 mg kg-1 BW [Ni (MPK-TSC) (Bipy)Cl2]; and Group F: treated with 200 mg kg-1 BW [Zn (MPK-TSC) (Bipy)Cl2]. Blood was collected via cardiac puncture for hematological analysis. Liver and kidney homogenates were used for plasma enzymes, liver and renal functions, and the antioxidant indices. The histological sections of rats' liver and kidney tissue samples were also examined.
Results: Animals from the control and different treated groups exhibited normal body weight gain throughout the dosing period of 28 days, except those treated with Bipy, with a marked decrease in body weight. The results of the study indicated that Bipy and MPK-TSC had significant adverse effects (P<0.05) on various biochemical indices.
Conclusion: As evidenced by the obtained results, combining MPK-TSC with metal ions resulted in a significant reduction in the toxicity of these compounds.
Methods: A total of 36 male rats weighing 178.12±5.48 g were assigned to six groups of six per group. Group A: administered 5% DMSO; Group B: treated with 200 mg kg-1 BW of 2, 2-Bipyridine; Group C: treated with 200 mg kg-1 BW MPK-TSC; Group D: treated with 200 mg kg-1 body weight [Cu (MPK-TSC) (Bipy)Cl2]; Group E: treated with 200 mg kg-1 BW [Ni (MPK-TSC) (Bipy)Cl2]; and Group F: treated with 200 mg kg-1 BW [Zn (MPK-TSC) (Bipy)Cl2]. Blood was collected via cardiac puncture for hematological analysis. Liver and kidney homogenates were used for plasma enzymes, liver and renal functions, and the antioxidant indices. The histological sections of rats' liver and kidney tissue samples were also examined.
Results: Animals from the control and different treated groups exhibited normal body weight gain throughout the dosing period of 28 days, except those treated with Bipy, with a marked decrease in body weight. The results of the study indicated that Bipy and MPK-TSC had significant adverse effects (P<0.05) on various biochemical indices.
Conclusion: As evidenced by the obtained results, combining MPK-TSC with metal ions resulted in a significant reduction in the toxicity of these compounds.
Keywords: 2, 2-Bipyridine, Metal ion complexation, Methylphenyl ketone, Sub-chronic toxicity, Thiosemicarbazone
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
