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Volume 18, Issue 3 (July 2024)
IJT 2024, 18(3): 138-143 |
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Zhanataev A K, Lisitsyn A A, Anisina E A, Kulakova A V, Kulakova A V, Malikova A D, et al . Red Beetroot Extract is Safe to DNA and Protects Against Mutagens in Mice: A Potential Chemopreventive Agent. IJT 2024; 18 (3) :138-143
URL: http://ijt.arakmu.ac.ir/article-1-1324-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1324-en.html
Aliy K Zhanataev1 
, Artem A Lisitsyn2 , Elena A Anisina3 , Alla V Kulakova4 , Alla V Kulakova4 , Aleksandra D Malikova * 5, Kira L Pligina4 , Zlata V Chaika3 , Irina M Chernukha6
, Artem A Lisitsyn2 , Elena A Anisina3 , Alla V Kulakova4 , Alla V Kulakova4 , Aleksandra D Malikova * 5, Kira L Pligina4 , Zlata V Chaika3 , Irina M Chernukha6
1- Head of the Laboratory of Genetic and Reproductive Toxicology, Federal Research Center for Innovative and Emerging Biomedical and Pharmaceutical Technologies, Department of Drug Toxicology. Moscow, Russia.
2- Junior Researcher; Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Department of Drug Toxicology. Moscow, Russia
3- Researcher; Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Department of Drug Toxicology. Moscow, Russia
4- Senior Researcher; Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Department of Drug Toxicology. Moscow, Russia
5- Junior Researcher; Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Department of Drug Toxicology. Moscow, Russia ,kirapligina@yandex.ru
6- Head of the Department of International and Initiative Projects Coordination, V.M. Gorbatov Federal Research Center for Food Systems, Department of International and Initiative Projects Coordination. Moscow, Russia
2- Junior Researcher; Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Department of Drug Toxicology. Moscow, Russia
3- Researcher; Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Department of Drug Toxicology. Moscow, Russia
4- Senior Researcher; Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Department of Drug Toxicology. Moscow, Russia
5- Junior Researcher; Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Department of Drug Toxicology. Moscow, Russia ,
6- Head of the Department of International and Initiative Projects Coordination, V.M. Gorbatov Federal Research Center for Food Systems, Department of International and Initiative Projects Coordination. Moscow, Russia
Abstract: (511 Views)
Background: The beetroot extract has long been widely used in the food industry. However, information on its genetic safety is insufficient. In addition, there is evidence to suggest its potential beneficial health effects. The aim of this study was to evaluate the genotoxic and antigenotoxic potentials of red beetroot extract in rats.
Methods: The endpoints analyzed were chromosomal aberrations in bone marrow cells and DNA damage in peripheral blood, liver, kidneys, and gastrointestinal tract cells assessed using the alkaline comet assay.
Results: There were no statistically significant differences between the analyzed data from the negative control and those of the groups treated with doses of beetroot extract up to 2000 mg/kg for both of the study endpoints. The findings demonstrated the absence of genotoxicity. The comet assay revealed considerable antigenotoxicity of the beetroot extract (5-100 mg/kg) in the liver, stomach, duodenum, and rectum versus the effects of methyl methanesulfonate and dioxidine mutagens with different mechanisms of action. No anticlastogenic activities were detected in the bone marrow cells while observing the protective effects on blood cells, indicating the tissue specificity for beetroot extract antigenotoxicity.
Conclusion: Based on the study findings, the beetroot extract meets the basic requirements for being a chemopreventive agent. The advantages are low cost, practicality of use, efficacy, and safety. Moreover, this agent may be used to develop food products with chemopreventive properties.
Methods: The endpoints analyzed were chromosomal aberrations in bone marrow cells and DNA damage in peripheral blood, liver, kidneys, and gastrointestinal tract cells assessed using the alkaline comet assay.
Results: There were no statistically significant differences between the analyzed data from the negative control and those of the groups treated with doses of beetroot extract up to 2000 mg/kg for both of the study endpoints. The findings demonstrated the absence of genotoxicity. The comet assay revealed considerable antigenotoxicity of the beetroot extract (5-100 mg/kg) in the liver, stomach, duodenum, and rectum versus the effects of methyl methanesulfonate and dioxidine mutagens with different mechanisms of action. No anticlastogenic activities were detected in the bone marrow cells while observing the protective effects on blood cells, indicating the tissue specificity for beetroot extract antigenotoxicity.
Conclusion: Based on the study findings, the beetroot extract meets the basic requirements for being a chemopreventive agent. The advantages are low cost, practicality of use, efficacy, and safety. Moreover, this agent may be used to develop food products with chemopreventive properties.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
