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Volume 18, Issue 3 (July 2024)
IJT 2024, 18(3): 166-181 |
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Ethics code: AZHAR, 25/2022
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Attya A M, Ashry M, Abdelreheem A M, El-Sahra D G, Abdel-Aal M A. Anti-Colon Cancer Activity of Nano-synthetic Quinolone: In vivo and In vitro Study. IJT 2024; 18 (3) :166-181
URL: http://ijt.arakmu.ac.ir/article-1-1327-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1327-en.html
Asmaa Mohammed Attya1 
, Mahmoud Ashry *2 
, Abdelbaset M.A. Abdelreheem1 , Doaa Galal El-Sahra3 , Mohammed A. Abdel-Aal4
, Mahmoud Ashry *2 , Abdelbaset M.A. Abdelreheem1 , Doaa Galal El-Sahra3 , Mohammed A. Abdel-Aal4
1- Zoology Dept, Faculty of Science, Al-Azhar University, Assuit, Egypt
2- Zoology Dept, Faculty of Science, Al-Azhar University, Assuit, Egypt ,mahmoud_ashry20@yahoo.com
3- Modern University for Technology and Information, Cairo, Egypt.
4- Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assuit, Egypt.
2- Zoology Dept, Faculty of Science, Al-Azhar University, Assuit, Egypt ,
3- Modern University for Technology and Information, Cairo, Egypt.
4- Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assuit, Egypt.
Abstract: (692 Views)
Background: Colon cancer is one of the most prevalent malignancies in both men and women. This study investigated the anticancer efficacy of a new synthetic form of quinolone nanoparticles (QNPs) against colon cancer cells. As an experimental model, we investigated methods to prevent the development of colon cancer in adult male albino rats induced by 1,2-dimethylhydrazine (DMH).
Methods: Forty adult male rats (weighing 150-200 g) were randomly assigned to four groups of ten as follows:
Group 1: Normal rats considered the reference group.
Group 2: Normal rats treated intraperitoneally with 100 μg/kg/day of quinolone.
Group 3: Rats with induced colon cancer by DMH.
Group 4: Rats with colon cancer, as the experimental model, and administered QNPs at 100 μg/kg/day for 6 weeks.
Results: The results showed that QNPs significantly improved the treatment of induced colon cancer in rats. This finding was supported by significant increases in CD4, colon SOD, and GPx activity, as well as in GSH and CAT levels. Further discoveries included a significant decline in the serum values of CEA, CA19-9, AFP, TNF-α, IL1β, ALT, AST, urea, creatinine, cholesterol, triglycerides, colon DNA damage, MDA, and NO. The histopathological results demonstrated the therapeutic potential of QNPs, which were successful in halting the development of colon cancer in an experimental animal model.
Conclusions: The findings of the current study demonstrated that QNPs were able to prevent colon cancer in rats by enhancing their immune system, lowering inflammatory markers, and improving damaged oxidative stress tolerance.
Methods: Forty adult male rats (weighing 150-200 g) were randomly assigned to four groups of ten as follows:
Group 1: Normal rats considered the reference group.
Group 2: Normal rats treated intraperitoneally with 100 μg/kg/day of quinolone.
Group 3: Rats with induced colon cancer by DMH.
Group 4: Rats with colon cancer, as the experimental model, and administered QNPs at 100 μg/kg/day for 6 weeks.
Results: The results showed that QNPs significantly improved the treatment of induced colon cancer in rats. This finding was supported by significant increases in CD4, colon SOD, and GPx activity, as well as in GSH and CAT levels. Further discoveries included a significant decline in the serum values of CEA, CA19-9, AFP, TNF-α, IL1β, ALT, AST, urea, creatinine, cholesterol, triglycerides, colon DNA damage, MDA, and NO. The histopathological results demonstrated the therapeutic potential of QNPs, which were successful in halting the development of colon cancer in an experimental animal model.
Conclusions: The findings of the current study demonstrated that QNPs were able to prevent colon cancer in rats by enhancing their immune system, lowering inflammatory markers, and improving damaged oxidative stress tolerance.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
