The protective effects of Cichorium intybus hydroalcoholic extract on the liver histopathologic effects of subchronic aluminum chloride in mice

Nabipour, Abolghasem; Darban Maghami, Naser; Moghadam Jafari, Amir; Moosavi, Zahra

doi:10.32592/IJT.19.1.45

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Volume 19, Issue 1 (2-2025) IJT 2025, 19(1): 45-51 | Back to browse issues page

‎ 10.32592/IJT.19.1.45

Ethics code: IR.UM. REC.1400.301

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Nabipour A, Darban Maghami N, Moghadam Jafari A, Moosavi Z. The protective effects of Cichorium intybus hydroalcoholic extract on the liver histopathologic effects of subchronic aluminum chloride in mice. IJT 2025; 19 (1) :45-51
URL: http://ijt.arakmu.ac.ir/article-1-1346-en.html

The protective effects of Cichorium intybus hydroalcoholic extract on the liver histopathologic effects of subchronic aluminum chloride in mice

Abolghasem Nabipour ^*

¹, Naser Darban Maghami²

, Amir Moghadam Jafari

, Zahra Moosavi³

1- Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran , nabipour@um.ac.ir
2- Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
3- Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran

Abstract: (98 Views)

Background: Aluminum is a potent inhibitor for many cation-dependent biological processes. Traditional medical practitioners for the treatment of liver disorders for centuries have used plant extracts The purpose of the study was to assess the hepatoprotective activity of hydroalcoholic extract of Cichorium intybus L. against aluminum chloride (Alcl3) intoxicated rats. Methods: The hepatoprotective activity of extracts (hydroalcoholic extract) at 50 mg/kg body weight was compared with aluminum chloride (Alcl3)-treated animals. The animals were divided into four groups with seven animals in each group. The first group represents control, the second group received aluminum chloride, the third group received C. intybus extract, and the fourth group received C. intybus plus aluminum chloride. The duration of injection was 15 days, injection was done by intraperitoneal method and the sampling was done one week after the last injection. Results: There were significant changes in serum biochemical parameters such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzyme in aluminum chloride intoxicated mice, which were restored towards normal values in C. intybus-treated animals. Histopathological examination of liver tissues further substantiated these findings.
Conclusion: The results ascertain that the herb extracts of C. intybus possess significant hepatoprotective activity.

Keywords: Aluminum chloride, Cichorium intybus, Hepatoprotective effects, Poisoning, Enzyme

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Type of Study: Research | Subject: Special

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