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Volume 19, Issue 1 (2-2025)
IJT 2025, 19(1): 26-36 |
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Ethics code: 256/PHS/2013
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Nwangwa J, Aribo E, Udefa A, Antai A. Cadmium-induced Reproductive Toxicity in Male Wistar Rats: Ameliorative effect of a Polyherbal Remedy, STC30. IJT 2025; 19 (1) :26-36
URL: http://ijt.arakmu.ac.ir/article-1-1352-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1352-en.html
1- Department of Physiology, University of Calabar, Calabar, Nigeria
2- Department of Physiology, University of Calabar, Calabar, Nigeria ,ekpearibo@gmail.com
2- Department of Physiology, University of Calabar, Calabar, Nigeria ,
Abstract: (299 Views)
Background: Cadmium-induced male infertility is associated with oxidative stress. However, there is a lack of literature regarding its effects on Cadmium-induced male reproductive toxicity, which is the motivation for conducting this study.
Methods: Twenty male Wistar rats were divided into four groups of five rats each as follows:1) Control; 2) Cadmium-only; 3) STC30-only; and 4) Cadmium+STC30. Daily administration was for 28 days, after which blood and testicular samples were collected for the determination of relevant parameters.
Results: The results demonstrated a significant loss of body weight in the Cadmium-only group compared to the control, Cadmium+STC30, and STC30-only groups. Testicular and epididymal weights were also significantly lower in the Cadmium-only group compared to the control, STC30-only, and Cadmium+STC30 groups. Furthermore, sperm count, viability, and motility were significantly diminished in the Cadmium-only group compared to the control, STC30-only, and Cadmium+STC30 groups. Teratozoospermia was significantly higher in the Cadmium-only group than in the control, Cadmium+STC30, and STC30-only groups. Levels of gonadotropin-releasing hormone, follicle-stimulating hormone, luteinizing hormone, and testosterone were significantly reduced in the Cadmium-only group compared to the control group.
Additionally, testicular malondialdehyde and TBARS levels were significantly elevated in the Cadmium-only group compared to the control, STC30-only, and Cadmium+STC30 groups. Activities of superoxide dismutase, glutathione peroxidase, catalase, and total antioxidant capacity in the testes were significantly lower in the Cadmium-only group compared to the control, STC30-only, and Cadmium+STC30 groups. Histological analysis revealed a significantly reduced Johnsen score in the Cadmium-only and Cadmium+STC30 groups compared to the control, with higher scores in the STC30-only and Cadmium+STC30 groups compared to the Cadmium-only group.
Conclusion: The STC30 compound ameliorated the Cadmium-induced male reproductive toxicity and oxidative stress in Wistar rats.
Methods: Twenty male Wistar rats were divided into four groups of five rats each as follows:1) Control; 2) Cadmium-only; 3) STC30-only; and 4) Cadmium+STC30. Daily administration was for 28 days, after which blood and testicular samples were collected for the determination of relevant parameters.
Results: The results demonstrated a significant loss of body weight in the Cadmium-only group compared to the control, Cadmium+STC30, and STC30-only groups. Testicular and epididymal weights were also significantly lower in the Cadmium-only group compared to the control, STC30-only, and Cadmium+STC30 groups. Furthermore, sperm count, viability, and motility were significantly diminished in the Cadmium-only group compared to the control, STC30-only, and Cadmium+STC30 groups. Teratozoospermia was significantly higher in the Cadmium-only group than in the control, Cadmium+STC30, and STC30-only groups. Levels of gonadotropin-releasing hormone, follicle-stimulating hormone, luteinizing hormone, and testosterone were significantly reduced in the Cadmium-only group compared to the control group.
Additionally, testicular malondialdehyde and TBARS levels were significantly elevated in the Cadmium-only group compared to the control, STC30-only, and Cadmium+STC30 groups. Activities of superoxide dismutase, glutathione peroxidase, catalase, and total antioxidant capacity in the testes were significantly lower in the Cadmium-only group compared to the control, STC30-only, and Cadmium+STC30 groups. Histological analysis revealed a significantly reduced Johnsen score in the Cadmium-only and Cadmium+STC30 groups compared to the control, with higher scores in the STC30-only and Cadmium+STC30 groups compared to the Cadmium-only group.
Conclusion: The STC30 compound ameliorated the Cadmium-induced male reproductive toxicity and oxidative stress in Wistar rats.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
