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Volume 19, Issue 1 (2-2025)
IJT 2025, 19(1): 26-36 |
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Ethics code: 256/PHS/2013
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Nwangwa J, Aribo E, Udefa A, Antai A. Cadmium-induced Reproductive Toxicity in Male Wistar Rats: Ameliorative effect of a Polyherbal Remedy, STC30. IJT 2025; 19 (1) :26-36
URL: http://ijt.arakmu.ac.ir/article-1-1352-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1352-en.html
1- Department of Physiology, University of Calabar, Calabar, Nigeria.
2- Department of Physiology, University of Calabar, Calabar, Nigeria. ,ekpearibo@gmail.com
2- Department of Physiology, University of Calabar, Calabar, Nigeria. ,
Abstract: (109 Views)
Background: Cadmium-induced male infertility is associated with oxidative stress. There are however no literature on its effect on Cadmium-induced male reproductive toxicity and hence this.
Methods: Twenty male wistar rats were separated into four groups of 5 rats each namely; control, Cadmium-only, STC30-only and Cadmium+STC30. Daily administration was for 28 days after which blood and testicular samples collected for determination of relevant parameters.
Results: The results showed significant body weight decrease in the Cadmium-only group compared with the control, Cadmium+STC30 and STC30-only (p<0.05). Testicular and epididymal weights were significantly reduced in the Cadmium-only compared with control, STC30-only and Cadmium+STC30 groups (p<0.05). Sperm count, viability and motility were significantly reduced in the Cadmium-only compared with the control (p<0.05) STC30-only and Cadmium+STC30 (p<0.05). Teratozotospermia was significantly elevated in the Cadmium-only compared with the control, Cadmium+STC30 and STC30-only (p<0.05). Gonadotropin-releasing hormone, follicle stimulating hormone, luteinizing hormone and testosterone were significantly reduced in the Cadmium-only compared with the control groups (p<0.05). Testicular malomdialdehyde and TBARS were significantly increased in the Cadmium-only (p<0.05) compared with the control, STC30-only and STC30+Cadmium (p<0.05). Superoxide dismutase, glutathione peroxidase, catalase activities and total antioxidant capacity in testes were significantly (p<0.05) reduced in the Cadmium-only compared with the control, STC30-only and Cadmium+STC30 groups. Sections of the testes showed significantly reduced Johnsen score in the Cadmium-only and Cadmium+STC30 groups compared with control (p<0.05), higher in STC30-only and Cd+STC30 than Cadmium-only. In conclusion, STC30 ameliorates Cadmium-induced male reproductive toxicity and oxidative stress in Wistar rats.
Methods: Twenty male wistar rats were separated into four groups of 5 rats each namely; control, Cadmium-only, STC30-only and Cadmium+STC30. Daily administration was for 28 days after which blood and testicular samples collected for determination of relevant parameters.
Results: The results showed significant body weight decrease in the Cadmium-only group compared with the control, Cadmium+STC30 and STC30-only (p<0.05). Testicular and epididymal weights were significantly reduced in the Cadmium-only compared with control, STC30-only and Cadmium+STC30 groups (p<0.05). Sperm count, viability and motility were significantly reduced in the Cadmium-only compared with the control (p<0.05) STC30-only and Cadmium+STC30 (p<0.05). Teratozotospermia was significantly elevated in the Cadmium-only compared with the control, Cadmium+STC30 and STC30-only (p<0.05). Gonadotropin-releasing hormone, follicle stimulating hormone, luteinizing hormone and testosterone were significantly reduced in the Cadmium-only compared with the control groups (p<0.05). Testicular malomdialdehyde and TBARS were significantly increased in the Cadmium-only (p<0.05) compared with the control, STC30-only and STC30+Cadmium (p<0.05). Superoxide dismutase, glutathione peroxidase, catalase activities and total antioxidant capacity in testes were significantly (p<0.05) reduced in the Cadmium-only compared with the control, STC30-only and Cadmium+STC30 groups. Sections of the testes showed significantly reduced Johnsen score in the Cadmium-only and Cadmium+STC30 groups compared with control (p<0.05), higher in STC30-only and Cd+STC30 than Cadmium-only. In conclusion, STC30 ameliorates Cadmium-induced male reproductive toxicity and oxidative stress in Wistar rats.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
