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Volume 18, Issue 3 (July 2024)
IJT 2024, 18(3): 182-188 |
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Ethics code: IR.IAU.KHUISF.REC.1400.293
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Pira M, Jalali Dehkordi K, Taghian F, Nasiri R. The effect of Frl-ZnO and aerobic exercise on the prevention of breast cancer in a mouse model of breast cancer. IJT 2024; 18 (3) :182-188
URL: http://ijt.arakmu.ac.ir/article-1-1359-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1359-en.html
1- PhD Student, Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University. Isfahan, Iran
2- Associate Professor, Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University. Isfahan, Iran ,khosrojalali@gmail.com
3- Associate Professor, Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University. Isfahan, Iran
4- National Elite Foundation. Tehran, Iran
2- Associate Professor, Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University. Isfahan, Iran ,
3- Associate Professor, Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University. Isfahan, Iran
4- National Elite Foundation. Tehran, Iran
Abstract: (147 Views)
Background: Breast cancer accounts for 23% of all neoplasias in women, which significantly impacts their physical, mental, and social aspects of life. This study investigated the effect of 8-week aerobic exercise alone or with ferulic acid administration combined with or without zinc oxide on the prevention of breast cancer in a rat model.
Methods: A total of 27 rats were randomly divided into 9 groups of 3 rats each as follows: 1) Exercise only; 2) Exercise + ferulic acid; 3) Exercise + zinc; 4) Exercise + ferulic + zinc; 5) Ferulic acid only; 6 ) Zinc; 7) Ferulic + zinc; 8) Positive controls; and 9) Negative controls. In the first week, the aerobic exercise protocol consisted of a 10-minute warm-up period at a speed of 10 m/min for 20 min, which increased to a speed of 18 m/min for 30 min. The ferulic acid supplement was administered to rats intraperitoneally using insulin syringes with a volume of 200 µL. After the last training session, the rats’ breast tissue samples were excised, and the expression levels of BCL2, Bax, and caspase-3 were measured by the real-time polymerase chain reaction method. The data were analyzed by one-way ANOVA and Tukey’s post hoc test (P≥0.05).
Results: The findings showed that intermittent exercise plus ferulic acid-zinc supplementation decreased the BCL2 level in the breast cancer group (P=0.004). Intermittent training supplemented with ferulic acid-zinc increased Bax and caspase-3 levels in the breast cancer group (P=0.001).
Conclusion: Aerobic exercise combined with ferulic acid and zinc nanoparticles inhibited cell apoptosis promoted by breast cancer in rats.
Methods: A total of 27 rats were randomly divided into 9 groups of 3 rats each as follows: 1) Exercise only; 2) Exercise + ferulic acid; 3) Exercise + zinc; 4) Exercise + ferulic + zinc; 5) Ferulic acid only; 6 ) Zinc; 7) Ferulic + zinc; 8) Positive controls; and 9) Negative controls. In the first week, the aerobic exercise protocol consisted of a 10-minute warm-up period at a speed of 10 m/min for 20 min, which increased to a speed of 18 m/min for 30 min. The ferulic acid supplement was administered to rats intraperitoneally using insulin syringes with a volume of 200 µL. After the last training session, the rats’ breast tissue samples were excised, and the expression levels of BCL2, Bax, and caspase-3 were measured by the real-time polymerase chain reaction method. The data were analyzed by one-way ANOVA and Tukey’s post hoc test (P≥0.05).
Results: The findings showed that intermittent exercise plus ferulic acid-zinc supplementation decreased the BCL2 level in the breast cancer group (P=0.004). Intermittent training supplemented with ferulic acid-zinc increased Bax and caspase-3 levels in the breast cancer group (P=0.001).
Conclusion: Aerobic exercise combined with ferulic acid and zinc nanoparticles inhibited cell apoptosis promoted by breast cancer in rats.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
