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Volume 19, Issue 1 (2-2025)
IJT 2025, 19(1): 9-16 |
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Ethics code: UM/HA/UGP 23.24 049/085.
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William E, John L, Lorna Hamman L, Orendu Oche Attah M, Isaac Dibal N, Ishaya Bedan H. Alium cepa Peel Extract Plays a Protective Role in Ethanol-Induced Kidney and Liver Toxiicity in Balb/C Mice: A Histological Study.. IJT 2025; 19 (1) :9-16
URL: http://ijt.arakmu.ac.ir/article-1-1390-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1390-en.html
Emmanuel William1 
, Lydia John1 , Luteino Lorna Hamman1 
, Martha Orendu Oche Attah *2 , Nathan Isaac Dibal1 , Helga Ishaya Bedan1
, Lydia John1 , Luteino Lorna Hamman1 , Martha Orendu Oche Attah *2 , Nathan Isaac Dibal1 , Helga Ishaya Bedan1
1- University of Maiduguri, Faculty of Basic Medical Sciences, Department of Human Anatomy, Maiduguri, Nigeria
2- University of Maiduguri, Faculty of Basic Medical Sciences, Department of Human Anatomy, Maiduguri, Nigeria & Faculty of Medicine, Cyprus International University, Nicosia, Cyprus ,marthaorendua@unimaid.edu.ng
2- University of Maiduguri, Faculty of Basic Medical Sciences, Department of Human Anatomy, Maiduguri, Nigeria & Faculty of Medicine, Cyprus International University, Nicosia, Cyprus ,
Abstract: (278 Views)
Background: Allium cepa peels are byproducts obtained from the onion bulb, which has abundant bioactive components that have been used in the treatment of various ailments across the globe. The current study investigates the effect of Allium cepa on the histology of the kidney and liver tissue following alcohol toxicity.
Methods: A total of 24 Balb/C mice, three months old and weighing 15-22 g, were grouped into four groups of 6 mice each. They were administered treatment as follows: Group I was considered the positive control and received an equal volume of distilled water; Group II (negative control) was administered 20% ethanol at 10 mg/kg; Group III was administered 50 g/kg of Allium cepa peel extract and 20% ethanol at 10 ml/kg; and Group IV received 100 g/kg of Allium cepa peel extract and 20% ethanol at 10 ml/kg. The treatment continued for 28 days, after which the mice were sacrificed, and the liver and kidney tissues were dissected for routine histological preparation.
Results: Administration of Allium cepa extract caused a non-significant increase in the body weight in treated groups, significantly (P<0.05) increased the weight of the kidneys, significantly (P<0.05) decreased in the weight of the liver, preserved the hepatocytes in the liver and the renal epithelium and glomerulus of the kidney tissue.
Conclusion: Allium cepa, in the present investigation, shows potential as a candidate to protect against ethanol-induced hepatotoxicity through its effects on renal and hepatic tissue. However, further studies are required to determine the exact mechanisms involved and the active biocomponents.
Methods: A total of 24 Balb/C mice, three months old and weighing 15-22 g, were grouped into four groups of 6 mice each. They were administered treatment as follows: Group I was considered the positive control and received an equal volume of distilled water; Group II (negative control) was administered 20% ethanol at 10 mg/kg; Group III was administered 50 g/kg of Allium cepa peel extract and 20% ethanol at 10 ml/kg; and Group IV received 100 g/kg of Allium cepa peel extract and 20% ethanol at 10 ml/kg. The treatment continued for 28 days, after which the mice were sacrificed, and the liver and kidney tissues were dissected for routine histological preparation.
Results: Administration of Allium cepa extract caused a non-significant increase in the body weight in treated groups, significantly (P<0.05) increased the weight of the kidneys, significantly (P<0.05) decreased in the weight of the liver, preserved the hepatocytes in the liver and the renal epithelium and glomerulus of the kidney tissue.
Conclusion: Allium cepa, in the present investigation, shows potential as a candidate to protect against ethanol-induced hepatotoxicity through its effects on renal and hepatic tissue. However, further studies are required to determine the exact mechanisms involved and the active biocomponents.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
