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Volume 19, Issue 4 (October 2025)
IJT 2025, 19(4): 248-258 |
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Ethics code: IR.UM.REC.1400.018
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Fasahi J, Baghshani H, Moosavi Z. Effect of Betaine Against Hepatotoxicity and Nephrotoxicity Associated With Acrylamide in Rats. IJT 2025; 19 (4) :248-258
URL: http://ijt.arakmu.ac.ir/article-1-1417-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1417-en.html
1- Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
2- Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran. ,baghishani@um.ac.ir
3- Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
2- Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran. ,
3- Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Abstract: (299 Views)
Background: This study aimed to investigate the effects of betaine on acrylamide (ACR)-induced damage in the liver and kidneys of rats.
Methods: A total of 28 male rats were divided into four groups. The first group served as the control. The second group received ACR (50 mg/kg body weight; i.p.) during the experiment (11 days). Group 3 received betaine (2% in diet) and ACR. Group 4 rats received betaine (2% in diet).
Results: Plasma alanine aminotransferase (ALT), aspartate aminotransferase, urea, creatinine, and bilirubin values increased significantly in Group 2 compared to the control group. Betaine treatment in Group 3 significantly decreased ALT values relative to Group 2. Hepatic glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), as well as renal GPx, SOD, fluorescence recovery after photobleaching (FRAP), and GSH values, showed a significant decline in Group 2 than in the controls. The hepatic and renal GPx, SOD, CAT, FRAP, and GSH levels in Group 3 notably increased to levels comparable to those of the control group. Additionally, a significant ascending trend in tissue protein carbonyl and malondialdehyde levels was observed in Group 2. In contrast, betaine treatment in the third group decreased these indices to levels comparable to those of the controls. Moreover, ACR-induced histopathological features, including a significant increase in hepatic hyperemia and necrosis, renal necrosis, and cell swelling, were attenuated by betaine treatment in Group 3.
Conclusion: These findings indicate that betaine can mitigate ACR-induced hepatotoxicity and nephrotoxicity, which may be related to betaine's antioxidant and methyl-donor potential.
Methods: A total of 28 male rats were divided into four groups. The first group served as the control. The second group received ACR (50 mg/kg body weight; i.p.) during the experiment (11 days). Group 3 received betaine (2% in diet) and ACR. Group 4 rats received betaine (2% in diet).
Results: Plasma alanine aminotransferase (ALT), aspartate aminotransferase, urea, creatinine, and bilirubin values increased significantly in Group 2 compared to the control group. Betaine treatment in Group 3 significantly decreased ALT values relative to Group 2. Hepatic glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), as well as renal GPx, SOD, fluorescence recovery after photobleaching (FRAP), and GSH values, showed a significant decline in Group 2 than in the controls. The hepatic and renal GPx, SOD, CAT, FRAP, and GSH levels in Group 3 notably increased to levels comparable to those of the control group. Additionally, a significant ascending trend in tissue protein carbonyl and malondialdehyde levels was observed in Group 2. In contrast, betaine treatment in the third group decreased these indices to levels comparable to those of the controls. Moreover, ACR-induced histopathological features, including a significant increase in hepatic hyperemia and necrosis, renal necrosis, and cell swelling, were attenuated by betaine treatment in Group 3.
Conclusion: These findings indicate that betaine can mitigate ACR-induced hepatotoxicity and nephrotoxicity, which may be related to betaine's antioxidant and methyl-donor potential.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
