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Volume 19, Issue 2 (April 2025)
IJT 2025, 19(2): 0-0 |
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Ethics code: 573/UN4.6.4.5.31/PP36/2024
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Prabawati A, Arsyad A, Santoso A, Djaharuddin I, Cangara H, Hidayah N et al . Comparison of Electronic Cigarette Smoke and Conventional Cigarette Smoke Exposure on Brain Histopathology and Brain Derived Neurotrophic Factor (BDNF) Level. IJT 2025; 19 (2)
URL: http://ijt.arakmu.ac.ir/article-1-1434-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1434-en.html
Andhira Prabawati1 
, Aryadi Arsyad *2 , Arif Santoso3 , Irawaty Djaharuddin3 , Husni Cangara4 , Nurul Hidayah1 , Masyta Nurul Jihad1
, Aryadi Arsyad *2 , Arif Santoso3 , Irawaty Djaharuddin3 , Husni Cangara4 , Nurul Hidayah1 , Masyta Nurul Jihad1
1- Magister Program in Biomedical Science, Postgraduate School, Hasanuddin University, Makassar, Indonesia
2- Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia ,aryadi.arsyad@med.unhas.ac.id
3- Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Hasanuddin University-Wahidin Sudirohusodo Hospital, Makassar, Indonesia
4- Department of Pathology Anatomy, Faculty of Medicine, Hasanuddin University Makassar, Indonesia
2- Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia ,
3- Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Hasanuddin University-Wahidin Sudirohusodo Hospital, Makassar, Indonesia
4- Department of Pathology Anatomy, Faculty of Medicine, Hasanuddin University Makassar, Indonesia
Abstract: (98 Views)
Objectives: The current study aimed to assess and compare the effects of exposure to electronic cigarette smoke and conventional cigarette smoke on the levels of Brain-Derived Neurotrophic Factor (BDNF) and the histopathological features of the brain in mice.
Methods: A total of 24 male Wistar rats were assigned to three groups: a control group (no exposure to cigarette smoke) and two experimental groups exposed to either regular cigarette smoke (1.8 mg nicotine, 32 mg tar, 25 minutes/day for 4 weeks) or electronic cigarette aerosol (1.8 mg/mL nicotine solution, 30 minutes/day for 30 days).
Result: The results indicated that the BDNF levels in the conventional cigarette group were 1.27 higher than the control group, demonstrating a relatively small difference. Meanwhile, the electronic cigarette group displayed a significant increase in BDNF levels compared to the control group (5.54; P=0.01) and the conventional cigarette group (4.27; P=0.009). Histopathologically, the electronic cigarette group had a higher level of brain tissue damage (79%) compared to the conventional cigarette group (75%) and the control group (25%).
Conclusion: The obtained results suggested that while electronic cigarette use is associated with a marked elevation in BDNF levels, it also correlates with higher levels of brain tissue damage compared to conventional cigarette use.
Methods: A total of 24 male Wistar rats were assigned to three groups: a control group (no exposure to cigarette smoke) and two experimental groups exposed to either regular cigarette smoke (1.8 mg nicotine, 32 mg tar, 25 minutes/day for 4 weeks) or electronic cigarette aerosol (1.8 mg/mL nicotine solution, 30 minutes/day for 30 days).
Result: The results indicated that the BDNF levels in the conventional cigarette group were 1.27 higher than the control group, demonstrating a relatively small difference. Meanwhile, the electronic cigarette group displayed a significant increase in BDNF levels compared to the control group (5.54; P=0.01) and the conventional cigarette group (4.27; P=0.009). Histopathologically, the electronic cigarette group had a higher level of brain tissue damage (79%) compared to the conventional cigarette group (75%) and the control group (25%).
Conclusion: The obtained results suggested that while electronic cigarette use is associated with a marked elevation in BDNF levels, it also correlates with higher levels of brain tissue damage compared to conventional cigarette use.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
