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Volume 19, Issue 2 (April 2025)
IJT 2025, 19(2): 83-91 |
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Ethics code: IR. DUMS. REC 1396. 17
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Eslamifar Z, Ghaffaripour R, Sabbagh S. Modulating Effect of Achillea Millefolium Extract on Cisplatin-Induced Nephrotoxicity. IJT 2025; 19 (2) :83-91
URL: http://ijt.arakmu.ac.ir/article-1-1444-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1444-en.html
1- Department of Medical Laboratory Sciences, Faculty of Paramedical Sciences, Dezful University of Medical Sciences, Dezful, Iran , eslamifar.z@gmail.com
2- Department of Medical Laboratory Sciences, Faculty of Paramedical Sciences, Dezful University of Medical Sciences, Dezful, Iran
3- Department of Anatomy, Faculty of Medicine, Dezful University of Medical Sciences, Dezful, Iran
2- Department of Medical Laboratory Sciences, Faculty of Paramedical Sciences, Dezful University of Medical Sciences, Dezful, Iran
3- Department of Anatomy, Faculty of Medicine, Dezful University of Medical Sciences, Dezful, Iran
Abstract: (288 Views)
Background: Cisplatin, as a strong chemotherapy drug, has many side effects, including nephrotoxicity, which is due to the accumulation of the drug in the cells of the proximal tubule of the kidney. One of the causes of cisplatin toxicity is the production of reactive oxygen species, which leads to oxidative stress, and eventually, kidney damage. Due to the importance of the topic, the present study aimed to investigate the modulating effects of Yarrow ethanolic extract, as an antioxidant compound, on cisplatin-induced toxicity in adult male Wistar rats.
Methods: Animals were divided into four groups: (1) control group (received normal saline for 10 days, i.p.), (2) cisplatin group (6 mg/kg on the fifth day, i.p.), (3) Yarrow group (250 mg/kg Yarrow ethanolic extract once a day for 10 days, gavage), (4) Cis-Yarrow group (250 mg/kg Yarrow extract once a day for 10 days [gavage] and 6 mg/kg cisplatin on the fifth day [i.p]). On the 11th day, all mice were anesthetized by diethyl ether, and plasma was collected to estimate urea, creatinine, uric acid, albumin, and TNFα. The right kidney was placed at -70 to study biochemical parameters.
Results: Renal toxicity caused by cisplatin was evident from high levels of creatinine, urea, uric acid, MDA, and TNFα, as well as decreased levels of SOD, CAT, GPX, GSH, and albumin. Administration of Yarrow extract significantly moderated the parameters of nephrotoxicity.
Conclusion: The results of the present research indicate that Yarrow extract has protective effects against cisplatin-induced nephrotoxicity; however, further studies are needed for clinical applications.
Methods: Animals were divided into four groups: (1) control group (received normal saline for 10 days, i.p.), (2) cisplatin group (6 mg/kg on the fifth day, i.p.), (3) Yarrow group (250 mg/kg Yarrow ethanolic extract once a day for 10 days, gavage), (4) Cis-Yarrow group (250 mg/kg Yarrow extract once a day for 10 days [gavage] and 6 mg/kg cisplatin on the fifth day [i.p]). On the 11th day, all mice were anesthetized by diethyl ether, and plasma was collected to estimate urea, creatinine, uric acid, albumin, and TNFα. The right kidney was placed at -70 to study biochemical parameters.
Results: Renal toxicity caused by cisplatin was evident from high levels of creatinine, urea, uric acid, MDA, and TNFα, as well as decreased levels of SOD, CAT, GPX, GSH, and albumin. Administration of Yarrow extract significantly moderated the parameters of nephrotoxicity.
Conclusion: The results of the present research indicate that Yarrow extract has protective effects against cisplatin-induced nephrotoxicity; however, further studies are needed for clinical applications.
Keywords: Biochemical Parameters, Cisplatin, Male Wistar Rats, Nephrotoxicity, Yarrow Ethanolic Extract
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
