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Volume 19, Issue 2 (April 2025)
IJT 2025, 19(2): 98-106 |
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Ethics code: 017/UH1.10/2024.
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Ratwita W, Mayzida A, Dewi A, Kaffah N, Maharani N, Pontjosudargo F, et al . Acute Toxicity Test of Ethanol Extract of Avocado Peel (Persea americana Mill.) in Female Mice (Mus musculus). IJT 2025; 19 (2) :98-106
URL: http://ijt.arakmu.ac.ir/article-1-1451-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1451-en.html
Welly Ratwita1 
, Afni Mayzida1 , Aninditha Dewi *2 , Nafisa Kaffah1 , Nurfadhiya Maharani1 , Fransiska Pontjosudargo3 , Evy Shavilla4 , Aprilia Sweetasari5
, Afni Mayzida1 , Aninditha Dewi *2 , Nafisa Kaffah1 , Nurfadhiya Maharani1 , Fransiska Pontjosudargo3 , Evy Shavilla4 , Aprilia Sweetasari5
1- Pharmacology, Department of Pharmacology, School of Medicine, Jenderal Achmad Yani University, Cimahi, Indonesia
2- Pharmacology, Department of Pharmacology, School of Medicine, Jenderal Achmad Yani University, Cimahi, Indonesia ,anindithalaras90@gmail.com
3- Anatomy, Department of Anatomy, School of Medicine, Jenderal Achmad Yani University, Cimahi, Indonesia
4- Ear, Nose, and Throat Specialist, Department of Ear, Nose, and Throat, School of Medicine, Jenderal Achmad Yani University, Cimahi, Indonesia
5- Neurologist, Department of Neurologi, School of Medicine, Jenderal Achmad Yani University, Cimahi, Indonesia
2- Pharmacology, Department of Pharmacology, School of Medicine, Jenderal Achmad Yani University, Cimahi, Indonesia ,
3- Anatomy, Department of Anatomy, School of Medicine, Jenderal Achmad Yani University, Cimahi, Indonesia
4- Ear, Nose, and Throat Specialist, Department of Ear, Nose, and Throat, School of Medicine, Jenderal Achmad Yani University, Cimahi, Indonesia
5- Neurologist, Department of Neurologi, School of Medicine, Jenderal Achmad Yani University, Cimahi, Indonesia
Abstract: (293 Views)
Background: Avocado peels (Persea americana Mill.) contain polyphenolic compounds that can be used as alternative medicinal plants, such as anti-inflammatory, antibacterial, and antifungal agents. This research aims to determine the acute toxicity of ethanol extract from avocado peels on ddY strain mice.
Methods: This experimental research using Acute Toxic Class Method (OECD 423) was conducted on 15 female mice ddY strain that were divided into five groups with one control group (CG) and four treatment groups. The four treatment groups administrated by ethanolic extract of avocado peel at Group 1 (G1) with 300 mg/kgBW single dose, Group 2 (G2) with 300 mg/kgBW repeated dose, Group 3 (G3) with 2,000 mg/kgBW single dose, and Group 4 (G4) with 2,000 mg/kgBW repeated dose were observed for 14 days.
Results: The results showed that avocado peels did not cause any toxic symptoms, including mortality (0%). No behavioral abnormalities or macroscopic changes in organ color, size, and relative organ weight were observed. Statistical analysis revealed no significant differences in the relative liver and kidney weight between the control and treatment groups (P>0.05). Although a reduction in body weight was noted, it was not statistically significant (P>0.05)
Conclusion: All doses of the ethanolic extract of avocado peels fall into the practically non-toxic category (category 5) based on Globally Harmonised System (GHS).
Methods: This experimental research using Acute Toxic Class Method (OECD 423) was conducted on 15 female mice ddY strain that were divided into five groups with one control group (CG) and four treatment groups. The four treatment groups administrated by ethanolic extract of avocado peel at Group 1 (G1) with 300 mg/kgBW single dose, Group 2 (G2) with 300 mg/kgBW repeated dose, Group 3 (G3) with 2,000 mg/kgBW single dose, and Group 4 (G4) with 2,000 mg/kgBW repeated dose were observed for 14 days.
Results: The results showed that avocado peels did not cause any toxic symptoms, including mortality (0%). No behavioral abnormalities or macroscopic changes in organ color, size, and relative organ weight were observed. Statistical analysis revealed no significant differences in the relative liver and kidney weight between the control and treatment groups (P>0.05). Although a reduction in body weight was noted, it was not statistically significant (P>0.05)
Conclusion: All doses of the ethanolic extract of avocado peels fall into the practically non-toxic category (category 5) based on Globally Harmonised System (GHS).
Keywords: Acute toxicity test, Avocado peel, Behavioral changes, Body weight, Macroscopic changes, Mortality
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
