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Volume 19, Issue 3 (July 2025)
IJT 2025, 19(3): 129-139 |
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Ethics code: IR.TBZMED.VCR.REC.1399.353
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Soltanieh N, Ostadi A, Mesgari-Abbasi M, Khordadmehr M, Behrouzi-Kahlan A, Banagozar Mohammadi A, et al . Effect of Different Concentrations of Aluminum Phosphide and (Sodium Bromide, Calcium Carbonate, and Potassium Nitrate) as Its Possible Antidotes on the Digestive and Reproductive System in a Rat Model. IJT 2025; 19 (3) :129-139
URL: http://ijt.arakmu.ac.ir/article-1-1452-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1452-en.html
Negin Soltanieh1 
, Ali Ostadi *2 , Mehran Mesgari-Abbasi1 , Monireh Khordadmehr3 , Azin Behrouzi-Kahlan1 , Ali Banagozar Mohammadi1 , Alireza Ghaffari1 , Ilghar Najafirad1
, Ali Ostadi *2 , Mehran Mesgari-Abbasi1 , Monireh Khordadmehr3 , Azin Behrouzi-Kahlan1 , Ali Banagozar Mohammadi1 , Alireza Ghaffari1 , Ilghar Najafirad1
1- Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2- Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ,ostadia@tbzmed.ac.ir
3- Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
2- Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ,
3- Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
Abstract: (559 Views)
Background: Aluminum phosphide (AlP) is often used as a suicide poison. Considering that there is no effective antidote, the present study aimed to investigate the toxic effect of ALP and evaluate the antidote potency of sodium bromide (NaBr), calcium carbonate (CaCO3), and potassium nitrate (KNO3) as antidotes.
Methods: In the first stage, 36 female Wistar rats were divided into six groups to receive AlP in different doses (0–40 mg/kg). After being sacrificed, the rats were histologically evaluated for the esophagus, stomach, pancreas, uterus, and ovary. In the second stage, animals were evaluated regarding the effect of AlP (20 mg/kg) on various fertility hormones, and subsequently, the role of proposed antidots was investigated to reverse the toxic changes.
Results: Histological findings did not show significant changes in all examined tissues. The studied hormonal changes showed a significant inverse relationship between AlP and luteinizing hormone (LH), prolactin, and estradiol hormones. In the works related to the studied antidotes, the results indicated that prolactin and estradiol decreased and increased, respectively, due to treatment with AlP compared to the control group.
Conclusion: Antidote studies revealed that the prolactin level in rats poisoned with AlP and treated with KNO3 was not different from the control group, and estradiol also returned to normal and control levels due to the treatment with KNO3 and NaBr. KNO3 was an efficient antidote against AlP toxicity regarding prolactin and estradiol among the tested antidotes, while NaBr successfully mitigated the effect of AlP toxicity.
Methods: In the first stage, 36 female Wistar rats were divided into six groups to receive AlP in different doses (0–40 mg/kg). After being sacrificed, the rats were histologically evaluated for the esophagus, stomach, pancreas, uterus, and ovary. In the second stage, animals were evaluated regarding the effect of AlP (20 mg/kg) on various fertility hormones, and subsequently, the role of proposed antidots was investigated to reverse the toxic changes.
Results: Histological findings did not show significant changes in all examined tissues. The studied hormonal changes showed a significant inverse relationship between AlP and luteinizing hormone (LH), prolactin, and estradiol hormones. In the works related to the studied antidotes, the results indicated that prolactin and estradiol decreased and increased, respectively, due to treatment with AlP compared to the control group.
Conclusion: Antidote studies revealed that the prolactin level in rats poisoned with AlP and treated with KNO3 was not different from the control group, and estradiol also returned to normal and control levels due to the treatment with KNO3 and NaBr. KNO3 was an efficient antidote against AlP toxicity regarding prolactin and estradiol among the tested antidotes, while NaBr successfully mitigated the effect of AlP toxicity.
Keywords: Aluminum phosphide (AlP), antidote, calcium carbonate (CaCO3), potassium nitrate (KNO3), rice tablets, sodium bromide (NaBr)
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
