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Kosisochukwu Arinze1 
, Olufemi Amole1 , Adeyemi Dada2 , Abdulfatai Ojewale3 , Edobor Emiogun4 , Omoniyi Yemitan *5
, Olufemi Amole1 , Adeyemi Dada2 , Abdulfatai Ojewale3 , Edobor Emiogun4 , Omoniyi Yemitan *5
1- Department of Pharmacology, Therapeutics and Toxicology, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria.
2- Department of Chemical Pathology, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria.
3- Department of Anatomy, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria.
4- Department of Pathology and Forensic Medicine, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria.
5- Department of Pharmacology, Therapeutics and Toxicology, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria. ,omoniyi.yemitan@lasucom.edu.ng
2- Department of Chemical Pathology, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria.
3- Department of Anatomy, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria.
4- Department of Pathology and Forensic Medicine, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria.
5- Department of Pharmacology, Therapeutics and Toxicology, Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria. ,
Abstract: (137 Views)
Background: Carica papaya plant parts have been documented for treating liver injuries in ethnomedicine despite the limited comparison of the anti-hepatotoxic properties of individual parts. This study compared the antihepatotoxic effects of hydroethanol leaf extract of C. papaya (HELC) and aqueous unripe fruit extract of C. papaya (AUFC) against paracetamol-induced hepatotoxicity in rats.
Methods: Thirty male rats were randomly allotted to six groups (n = 5). Liver injury was induced by paracetamol (600 mg/kg, p.o.) in all groups except the normal group. Then, HELC or AUFC was administered at 200 mg/kg and 400 mg/kg to each group at 2, 6, and 10 h. Twenty-four hours later, blood samples were collected to evaluate the serum levels of Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), and uric acid and confirmed by histopathological examination of the liver tissue.
Results: A significant (P<0.05) and dose-dependent reduction in the ALT, AST, and uric acid serum levels in the HELC and AUFC treatment groups compared with the control. Serum levels of the markers were generally lowered at 400 mg/kg rather than 200 mg/kg for each of HELC and AUFC. However, no statistically significant dose-dependent values were recorded. Also, at 400 mg/kg, HELC produced the highest reduction of the markers among all treatment groups, confirmed by histopathological findings.
Conclusion: Both HELC and AUFC showed antihepatotoxic effects. At higher doses, HELC produced a greater antihepatotoxic effect than AUFC. However, these comparative effects were not statistically significant.
Methods: Thirty male rats were randomly allotted to six groups (n = 5). Liver injury was induced by paracetamol (600 mg/kg, p.o.) in all groups except the normal group. Then, HELC or AUFC was administered at 200 mg/kg and 400 mg/kg to each group at 2, 6, and 10 h. Twenty-four hours later, blood samples were collected to evaluate the serum levels of Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), and uric acid and confirmed by histopathological examination of the liver tissue.
Results: A significant (P<0.05) and dose-dependent reduction in the ALT, AST, and uric acid serum levels in the HELC and AUFC treatment groups compared with the control. Serum levels of the markers were generally lowered at 400 mg/kg rather than 200 mg/kg for each of HELC and AUFC. However, no statistically significant dose-dependent values were recorded. Also, at 400 mg/kg, HELC produced the highest reduction of the markers among all treatment groups, confirmed by histopathological findings.
Conclusion: Both HELC and AUFC showed antihepatotoxic effects. At higher doses, HELC produced a greater antihepatotoxic effect than AUFC. However, these comparative effects were not statistically significant.
Keywords: Carica papaya, paracetamol, Antihepatotoxic, Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Uric acid, histopathologic examination
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
