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Emam Atiyah Ibadi IBADI *1 
, Hussein Kamil Awad Awad2 , Zainab Hudhi Farhoord Farhoord3 , Bilal Husam Jasim Jasim4 , Sabrean Farhan Jawad Jawad5
, Hussein Kamil Awad Awad2 , Zainab Hudhi Farhoord Farhoord3 , Bilal Husam Jasim Jasim4 , Sabrean Farhan Jawad Jawad5
1- Department of Environment, College of Science, University of Al-Qadisiyah, Diwaniyah, Iraq. , emam.atiyah@qu.edu.iq
2- Unit of Environment and Prevention of Pollution, College of Science, University of Al-Qadisiyah, Diwaniyah, Iraq
3- Department of biology, Faculty of Education for Pure Science, University of Thi-Qar
4- Biotechnology Department, Collage of Applied Sciences, University of Technology – Iraq
5- College of pharmacy Al- Mustaqbal University, 51001 Babil, Iraq
2- Unit of Environment and Prevention of Pollution, College of Science, University of Al-Qadisiyah, Diwaniyah, Iraq
3- Department of biology, Faculty of Education for Pure Science, University of Thi-Qar
4- Biotechnology Department, Collage of Applied Sciences, University of Technology – Iraq
5- College of pharmacy Al- Mustaqbal University, 51001 Babil, Iraq
Abstract: (153 Views)
Background: Orlistat, while reducing dietary fat absorption for obesity, presents risks: pancreatic, hepatic, renal, and cerebellar damage.
Methods: This study investigated Orlistat heart and lung toxicity, lacking in prior research. Male rats were split for five set (five each group): group 1, (C/A) was normal diet ; group 2, (C/B): Was given 30% the high fat diet; group 3, (OS-360 mg/kg); group 4, (OS-480 mg/kg); group 5, (OS-600 mg/kg). Rats were administered orally daily for 60 days.
Results: The obtained results from heart tissues that orlistat induces dose-dependent oxidative stress, evidenced by increased Reactive Oxygen Species (ROS) and altered peroxiredoxin, may have deleterious effects on heart tissue and may not protect against high-fat diet-induced damage. Also in lung tissues high-dose Glutathione S-Transferase (GST) increase, biphasic ROS response, and peroxiredoxin changes with fat/low-dose Orlistat. Orlistat may have adverse effects on lung tissue, and may not protect against damage caused by a high-fat diet.
Conclusion: The orlistat have adverse heart and lung effects and dose-dependent oxidative stress.
Methods: This study investigated Orlistat heart and lung toxicity, lacking in prior research. Male rats were split for five set (five each group): group 1, (C/A) was normal diet ; group 2, (C/B): Was given 30% the high fat diet; group 3, (OS-360 mg/kg); group 4, (OS-480 mg/kg); group 5, (OS-600 mg/kg). Rats were administered orally daily for 60 days.
Results: The obtained results from heart tissues that orlistat induces dose-dependent oxidative stress, evidenced by increased Reactive Oxygen Species (ROS) and altered peroxiredoxin, may have deleterious effects on heart tissue and may not protect against high-fat diet-induced damage. Also in lung tissues high-dose Glutathione S-Transferase (GST) increase, biphasic ROS response, and peroxiredoxin changes with fat/low-dose Orlistat. Orlistat may have adverse effects on lung tissue, and may not protect against damage caused by a high-fat diet.
Conclusion: The orlistat have adverse heart and lung effects and dose-dependent oxidative stress.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
