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Modupe Akingbade1 
, Ekpe Ekpe Asuquo1 , Charles Oluwafemi Faeji *2 , Olabode Olaniran3 , Ayo Akinwande Fasoro4
, Ekpe Ekpe Asuquo1 , Charles Oluwafemi Faeji *2 , Olabode Olaniran3 , Ayo Akinwande Fasoro4
1- Department of Anatomy, Ekiti State University, Ado Ekiti, Nigeria.
2- Department of Science, College of West Anglia, Kings Lynn, England. ,charles.faeji@cwa.ac.uk
3- Independent Researcher, Leeds, England.
4- Department of Public Health, University of Otago, Wellington, New Zealand.
2- Department of Science, College of West Anglia, Kings Lynn, England. ,
3- Independent Researcher, Leeds, England.
4- Department of Public Health, University of Otago, Wellington, New Zealand.
Abstract: (17 Views)
Abstract
Background: About 10% to 15% of couples experience infertility, which is a serious health issue, with 40% of cases being attributed to male partners. Studies have reported that aspirin can induce reproductive toxicity, hence leading to infertility. Quercetin is a natural product and dietary supplement that has been utilized as an antioxidant and an anti-inflammatory. It is crucial to find an antioxidant that will increase fertility and lessen the harmful effects on male fertility. The purpose of this study was to assess quercetin's morphological and molecular effects on aspirin-induced testicular damage in Wistar rats.
Methods: Thirty-five adult male Wistar rats weighing between 150 and 200 grams were divided into seven groups. Olive oil and normal saline were administered to the two control groups. Aspirin (50 mg/kg/day), quercetin (30 mg/kg/day or 60 mg/kg/day), or a combination of aspirin and quercetin were administered to the remaining groups. The study lasted for 30 days, and assessments were conducted through morphological and molecular evaluations.
Results: The study found that animals in control, olive oil, and quercetin groups showed no significant increase in gross anatomical parameters or histomorphology but increased body weight, indicating an active growth phase. Quercetin treatment improved the sperm count, motility, and morphology of aspirin-induced groups, which also had some molecular and histomorphology alterations.
Conclusion: Quercetin's potential as a medicinal substance can substantially improve aspirin-induced testicular toxicity.
Background: About 10% to 15% of couples experience infertility, which is a serious health issue, with 40% of cases being attributed to male partners. Studies have reported that aspirin can induce reproductive toxicity, hence leading to infertility. Quercetin is a natural product and dietary supplement that has been utilized as an antioxidant and an anti-inflammatory. It is crucial to find an antioxidant that will increase fertility and lessen the harmful effects on male fertility. The purpose of this study was to assess quercetin's morphological and molecular effects on aspirin-induced testicular damage in Wistar rats.
Methods: Thirty-five adult male Wistar rats weighing between 150 and 200 grams were divided into seven groups. Olive oil and normal saline were administered to the two control groups. Aspirin (50 mg/kg/day), quercetin (30 mg/kg/day or 60 mg/kg/day), or a combination of aspirin and quercetin were administered to the remaining groups. The study lasted for 30 days, and assessments were conducted through morphological and molecular evaluations.
Results: The study found that animals in control, olive oil, and quercetin groups showed no significant increase in gross anatomical parameters or histomorphology but increased body weight, indicating an active growth phase. Quercetin treatment improved the sperm count, motility, and morphology of aspirin-induced groups, which also had some molecular and histomorphology alterations.
Conclusion: Quercetin's potential as a medicinal substance can substantially improve aspirin-induced testicular toxicity.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
