Enter your email address
Submit
Write your message
1- Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Semarang, Semarang, Indonesia.
2- Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Semarang, Semarang, Indonesia ,basanatha@mail.unnes.ac.id
3- Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Semarang, Semarang, Indonesia
2- Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Semarang, Semarang, Indonesia ,
3- Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Semarang, Semarang, Indonesia
Abstract: (29 Views)
Background: Hepatotoxicity is liver damage caused by exposure to xenobiotics, resulting when the liver is unable to detoxify free radicals, such as reactive oxygen species (ROS), or other harmful metabolites. Moringa oleifera has been reported to possess preventive and therapeutic potential against various diseases due to its extract and bioactive components, particularly quercetin, which plays a significant role in its hepatoprotective effects. The present study aimed to evaluate the hepatoprotective potential of ethanolic Moringa oleifera leaf extract in carbon tetrachloride (CCl₄)-induced rats.
Methods: A total of 25 male Wistar rats were divided into five groups: a negative control group (0.9% NaCl), a positive control group (CCl₄), and three treatment groups receiving Moringa oleifera extract at doses of 250 mg/kg body weight (D1), 500 mg/kg body weight (D2), and 1000 mg/kg body weight (D3), all previously induced with 10 % CCl₄ solution administered at 1 mL/kg body weight. Observations were made on aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, as well as relative liver weight.
Results: Administration of ethanolic Moringa oleifera leaf extract at all three doses significantly reduced AST and ALT levels compared to the CCl₄ group, indicating hepatoprotective effects. However, no significant differences in relative liver weight were observed among the treatment groups.
Conclusion: Ethanolic Moringa oleifera leaf extract exhibits hepatoprotective effects against CCl₄-induced liver injury through the reduction of AST and ALT levels by 46.5% and 37%, respectively, although it does not influence relative liver weight.
Methods: A total of 25 male Wistar rats were divided into five groups: a negative control group (0.9% NaCl), a positive control group (CCl₄), and three treatment groups receiving Moringa oleifera extract at doses of 250 mg/kg body weight (D1), 500 mg/kg body weight (D2), and 1000 mg/kg body weight (D3), all previously induced with 10 % CCl₄ solution administered at 1 mL/kg body weight. Observations were made on aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, as well as relative liver weight.
Results: Administration of ethanolic Moringa oleifera leaf extract at all three doses significantly reduced AST and ALT levels compared to the CCl₄ group, indicating hepatoprotective effects. However, no significant differences in relative liver weight were observed among the treatment groups.
Conclusion: Ethanolic Moringa oleifera leaf extract exhibits hepatoprotective effects against CCl₄-induced liver injury through the reduction of AST and ALT levels by 46.5% and 37%, respectively, although it does not influence relative liver weight.
Keywords: Alanine aminotransferase (ALT), Aminotransferase (AST), hepatoprotective, Moringa oleifera, Relative liver weight
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
