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Volume 20, Issue 3 (July 2026)
IJT 2026, 20(3): 155-159 |
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Ethics code: IR452844
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Hasanvand A, Jamalian M, Askarifard Jahromi M, Adineh A, Mohammadi M, Gholami M, et al . Hepatoprotective Effects of Carvacrol on Arsenic Trioxide–Induced Liver Toxicity in Rats. IJT 2026; 20 (3) :155-159
URL: http://ijt.arakmu.ac.ir/article-1-1557-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1557-en.html
Amin Hasanvand1 
, Mohammad Jamalian2 , Mahnoush Askarifard Jahromi3 , Ahmad Adineh4 , Mohsen Mohammadi5 , Mehrdad Gholami6 , Saeedeh Ahmadipour7 , Hamidreza Mohammadi *8
, Mohammad Jamalian2 , Mahnoush Askarifard Jahromi3 , Ahmad Adineh4 , Mohsen Mohammadi5 , Mehrdad Gholami6 , Saeedeh Ahmadipour7 , Hamidreza Mohammadi *8
1- Department of Physiology and Pharmacology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
2- Department of Forensic Medicine, School of Medicine, Valiasr Hospital, Arak University of Medical Sciences, Arak, Iran.
3- Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
4- Department of Toxicology, Faculty of Pharmacy, Razi Herbal Medicine Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
5- Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
6- Medical Physics Department, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
7- Department of Pharmaceutics, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran.
8- Department of Toxicology, Faculty of Pharmacy, Razi Herbal Medicine Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. ,hamidrezamohammadi65@yahoo.com
2- Department of Forensic Medicine, School of Medicine, Valiasr Hospital, Arak University of Medical Sciences, Arak, Iran.
3- Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
4- Department of Toxicology, Faculty of Pharmacy, Razi Herbal Medicine Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
5- Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
6- Medical Physics Department, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
7- Department of Pharmaceutics, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran.
8- Department of Toxicology, Faculty of Pharmacy, Razi Herbal Medicine Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. ,
Abstract: (24 Views)
Background: Arsenic trioxide (As2O3, ATO) is commonly used to treat acute promyelocytic leukemia (APL); however, a major challenge in its use is hepatotoxicity, which has gained increasing attention in recent years. Many patients undergoing ATO therapy experience varying degrees of liver damage. Since oxidative stress plays a key role in ATO-induced liver injury, this study aimed to explore the potential protective effects of carvacrol on ATO-induced liver damage in rats.
Methods: In this study, rats were treated with ATO (5 mg/kg) either alone or in combination with carvacrol at doses of 50, 100, or 200 mg/kg. At the end of the treatment, several liver injury biomarkers, including ALT, AST, LDH, and bilirubin, were measured. Additionally, oxidative stress indicators in liver tissue, such as lipid peroxidation, antioxidant capacity, ROS levels, and glutathione (GSH) content, were assessed.
Results: Arsenic trioxide treatment led to significant liver damage, marked by increased levels of liver injury biomarkers (ALT, AST, and LDH), along with disruptions in oxidative stress markers. These changes included increased lipid peroxidation, elevated ROS levels, and decreased liver GSH content and antioxidant capacity. Importantly, carvacrol treatment at all tested doses effectively reduced these harmful effects, highlighting its potential as a hepatoprotective agent.
Conclusion: Carvacrol exhibits strong antioxidant activity and has the capacity to effectively counteract ATO–induced oxidative liver injury.
Methods: In this study, rats were treated with ATO (5 mg/kg) either alone or in combination with carvacrol at doses of 50, 100, or 200 mg/kg. At the end of the treatment, several liver injury biomarkers, including ALT, AST, LDH, and bilirubin, were measured. Additionally, oxidative stress indicators in liver tissue, such as lipid peroxidation, antioxidant capacity, ROS levels, and glutathione (GSH) content, were assessed.
Results: Arsenic trioxide treatment led to significant liver damage, marked by increased levels of liver injury biomarkers (ALT, AST, and LDH), along with disruptions in oxidative stress markers. These changes included increased lipid peroxidation, elevated ROS levels, and decreased liver GSH content and antioxidant capacity. Importantly, carvacrol treatment at all tested doses effectively reduced these harmful effects, highlighting its potential as a hepatoprotective agent.
Conclusion: Carvacrol exhibits strong antioxidant activity and has the capacity to effectively counteract ATO–induced oxidative liver injury.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
