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:: Volume 7, Issue 23 (Winter 2014) ::
IJT 2014, 7(23): 940-943 Back to browse issues page
Comparison of Deferoxamine, Activated Charcoal, and Vitamin C in ‎Changing the Serum Level of Fe in Iron Overloaded Rats
Reza Ghafari , Jaber Gharehdaghi , Hassan‎ Solhi‎ *
‎ Department of Forensic Medicine, Arak University of Medical Sciences, Arak, Iran.‎ , solhi.h@arak.ac.ir
Abstract:   (4072 Views)
Background: Iron is an essential mineral for normal cellular physiology but its ‎overload can lead to cell injury. For many years, deferoxamine injection has been used ‎as an iron chelator for treatment of iron overload. The aim of this study is to compare ‎oral deferoxamine, activated charcoal, and vitamin C, as an absorbent factor of Fe, in ‎changing the serum level of iron in iron overload rats. ‎
Methods: In this experimental study, all groups were administered 150 mg iron dextran ‎orally by gavage. After eight hours, rats in the first group received oral deferoxamine ‎while those in the second and third groups received oral activated charcoal 1 mg/kg and ‎oral vitamin C 150 mg, respectively. Then, serum levels of iron ware measured in all ‎rats.‎
Results: The mean serum level of iron in rats that received oral deferoxamine was ‎‎258.11±10.49 µg/dl, whereas mean levels of iron in charcoal and vitamin C groups were ‎‎380.88±11.21 µg/dl and 401.22±13.28 µg/dl, respectively. None of the measurements ‎were within safety limits of serum iron.‎
Conclusion: It seems that oral deferoxamine per se may not help physicians in the ‎management of cases presented with iron toxicity. Activated charcoal did not reduce ‎serum iron significantly in this study and further investigations may be warranted to ‎assess the potential clinical utility of its mixture with oral deferoxamine as an adjunct in ‎the clinical management of iron ingestions. ‎
Keywords: Ascorbic Acid, Charcoal, Deferoxamine, Iron, Poisoning, Rats.‎
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Type of Study: Research | Subject: Special
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Ghafari R, Gharehdaghi J, Solhi‎ H. Comparison of Deferoxamine, Activated Charcoal, and Vitamin C in ‎Changing the Serum Level of Fe in Iron Overloaded Rats. IJT. 2014; 7 (23) :940-943
URL: http://ijt.arakmu.ac.ir/article-1-277-en.html
Volume 7, Issue 23 (Winter 2014) Back to browse issues page
مجله سم شناسی و مسمومیتهای ایران Iranian Journal of Toxicology
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