Volume 8, Issue 25 (Summer 2014)                   IJT 2014, 8(25): 1073-1080 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Najafi G, Nejati V, Shalizar Jalali A, Zahmatkesh E. Protective Role of Royal Jelly in Oxymetholone-induced Oxidative Injury in Mouse Testis. IJT. 2014; 8 (25) :1073-1080
URL: http://ijt.arakmu.ac.ir/article-1-326-en.html
Department of Basic Sciences, Urmia University, Urmia, Iran. , a.shalizar@urmia.ac.ir
Abstract:   (3628 Views)
Background: An adverse effect of oxymetholone (OXM), an anabolic-androgenic steroid used as energetic medicine, is reproductive toxicity. Royal jelly (RJ) is an efficient antioxidant that has been used to treat reproductive problems. In this study, we investigated the effects of RJ on OXM-induced oxidative injuries in mouse testes.
Methods: Male mice were divided into four groups. Two groups of mice were administered OXM (5 mg/kg/day, p.o.) for 28 days. One of these groups received RJ (100 mg/kg/day, p.o.) concurrently. A vehicle-treated control group and a RJ control group were also included.
Results: The OXM-treated group showed a significant decrease in the serum testosterone concentration and spermatogenic activities, along with many histological alterations. OXM treatment also caused a significant decrease in catalase activity with an increase in lipid peroxidation in the mouse testes. The above-noted parameters were restored to near normal levels by RJ co-administration.
Conclusion: The results demonstrate that RJ protects against OXM-induced reproductive toxicities.
Full-Text [PDF 422 kb]   (1828 Downloads)    
Type of Study: Research | Subject: Special

Add your comments about this article : Your username or Email:
CAPTCHA code

Send email to the article author


© 2019 All Rights Reserved | Iranian Journal of Toxicology

Designed & Developed by : Yektaweb