[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 9, Number 28 (Spring 2015) ::
IJT 2015, 9(28): 1239-1246 Back to browse issues page
Protective Effects of Silymarin Extract on Malthion-Induced Zebra Cichlid (Cichlasoma Nigrofasciatum) Hepatotoxicity
Mahdi Banaee *, Antoni Sureda, Shima Shahaf, Nastaran Fazilat
Department of Aquaculture, Behbahan Khatam Alanbia University of Technology, Behbahan, Iran. , banaee@bkatu.ac.ir
Abstract:   (2730 Views)
Background: There is much evidence indicating that natural substances from edible and medicinal plants possess powerful antioxidant and hepatoprotective activities. The objective of the present study was to investigate the potential hepatoprotective effect of silymarin in fish exposed to malathion.
Methods: Zebra cichlid fish were allocated into five groups of which one group received normal feed and served as control. Fish from group 2 were treated with 0.1 mg.L-1 malathion. Fish from group 3 and 4 were fed with enriched diet with 1400 mg and 2100 mg silymarin per 1 kg feed, respectively. While fish from group 5 and 6 were fed with enriched diet with 1400 mg and 2100 mg silymarin per 1 kg feed, respectively and simultaneously were treated with 0.1 mg.L-1 malathion for 15 days. Activities of hepatic enzymes including alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and lactate dehydrogenase were evaluated. Oxidative stress was ascertained by measuring malondialdehyde as marker of lipid peroxidation and total cellular antioxidant capacity.
Results: Exposure to malathion caused a significant increase in MDA levels and altered AST, ALT, ALP and LDH activities in liver tissues (p<0.05). The hepatic antioxidant capacity was significantly lowered in malathion treated fish as compared to the control group (p<0.05). Treatment with silymarin significantly ameliorated these changes in the malathion-treated groups.
Conclusion: These finding demonstrated that silymarin have protective effects against the toxic influence of malathion on the examined biochemical parameters in liver tissue of fish.
Keywords: Hepatic Enzymes, Hepatoprotective, Malathion, Oxidative Stress, Silymarin.
Full-Text [PDF 5330 kb]   (1365 Downloads)    
Type of Study: Research | Subject: Special
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Banaee M, Sureda A, Shahaf S, Fazilat N. Protective Effects of Silymarin Extract on Malthion-Induced Zebra Cichlid (Cichlasoma Nigrofasciatum) Hepatotoxicity. IJT. 2015; 9 (28) :1239-1246
URL: http://ijt.arakmu.ac.ir/article-1-406-en.html
Volume 9, Number 28 (Spring 2015) Back to browse issues page
مجله سم شناسی و مسمومیتهای ایران Iranian Journal of Toxicology
Persian site map - English site map - Created in 0.058 seconds with 797 queries by yektaweb 3506