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:: Volume 9, Number 30 (Autumn 2015) ::
IJT 2015, 9(30): 1360-1367 Back to browse issues page
Protective Effects of Vitamin C and Chitosan against Cadmium-Induced Oxidative Stress in the Liver of Common Carp (Cyprinuscarpio)
Milad Mehrpak, Mahdi Banaee *, Behzad Nematdoost Haghi, Ahmad Noori
Department of Aquaculture, Behbahan Khatam Alanbia University of Technology, Iran. , banaee@bkatu.ac.ir
Abstract:   (2385 Views)
Background: Cadmium (Cd) intoxication can cause oxidative stress and involve the antioxi-dant defense system in hepatocytes. Administration of vitamin C, chitosan, or a combination of both may prevent Cd-induced oxidative damage.
Methods:Cyprinus carpio were distributed into six groups. The control group received normal feed (Group I). Group II was exposed to 0.2 mg.L-1 cadmium chloride. Group III were fed 1000 mg chitosan per 1 kg feed. Group IV was exposed to 0.2 mg.L-1 cadmium chloride and fed with1000 mg chitosan per 1 kg feed while Group V was exposed to 0.2 mg.L-1 cadmium chlo-ride and was fed with 1000 mg vitamin C per 1 kg feed. Group VI, however, was exposed to 0.2 mg.L-1 cadmium chloride and was fed with 1000 mg vitamin C combined with 1000 mg chi-tosanper 1 kg feed. After 21 days of experiment, activities of hepatic enzymes and oxidative stress biomarkers were evaluated.
Results:Exposure to CdCl2 caused a significant increase in malondialdehyde levels and al-tered alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase activities in liver tissues. Hepatic antioxidant capacity, catalase, and Glucose-6-phosphate dehydrogenase activities significantly decreased in fishes exposed to CdCL2 as compared to the control group. Treatment with vitamin C and vitamin C combined with chitosan significantly ameliorated these changes.
Conclusion:The present findings suggest that the administration of chitosan failed to restore biochemical parameters to normal levels. However, these findings demonstrate that vitamin C and vitamin C combined with chitosan protect the fish against the toxic effects of CdCl2 on the examined biochemical parameters in liver tissues.
Keywords: Cadmium, Chitosan, Hepatoprotective, Oxidative Stress, Vitamin C.
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Type of Study: Research | Subject: General
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Mehrpak M, Banaee M, Nematdoost Haghi B, Noori A. Protective Effects of Vitamin C and Chitosan against Cadmium-Induced Oxidative Stress in the Liver of Common Carp (Cyprinuscarpio). IJT. 2015; 9 (30) :1360-1367
URL: http://ijt.arakmu.ac.ir/article-1-455-en.html
Volume 9, Number 30 (Autumn 2015) Back to browse issues page
مجله سم شناسی و مسمومیتهای ایران Iranian Journal of Toxicology
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