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Volume 10, Issue 4 (July-August 2016)                   IJT 2016, 10(4): 21-24 | Back to browse issues page

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Keramati M R, Sadeghian M H, Ayatollahi H, Basharati M H, Jalili M, Balali Mood M. Evaluation of JAK2 (V617F) Mutation in Iranian Veterans with Delayed Complications of Sulphur Mustard Poisoning. IJT 2016; 10 (4) :21-24
URL: http://ijt.arakmu.ac.ir/article-1-485-en.html
Evaluation of JAK2 (V617F) Mutation in Iranian Veterans with Delayed Complications of Sulphur Mustard Poisoning
Mohammad Reza Keramati1 , Mohammad Hadi Sadeghian1 , Hossein Ayatollahi * 2, Mohammad Hosein Basharati3 , Mahshid Jalili4 , Mahdi Balali Mood5
1- PhD of Hematopathology, Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
2- PhD of Hematopathology, Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. , Ayatollahih@mums.ac.ir
3- MD, Mashhad University of Medical Sciences, Mashhad, Iran.
4- BSc of Laboratory Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
5- Department of Toxicology, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract:   (4290 Views)

Background: Sulfur mustard was the most widely applied chemical warfare agent by the Iraqi army in Iran–Iraq war (1983-1988). Considering the role of sulfur mustard toxicity in hematopoietic neoplasms and also new role of JAK2 mutation in these neoplasms, we assessed this mutation and delayed hematologic complications in veterans exposed to sulfur mustard.

Methods: This case control study was performed in Mashhad University of Medical Sciences, Mashhad, Iran in collaboration with Janbasan Foundation of Khorasan Razavi, Iran in 2012. The case group consists of 42 patients who exposed to sulfur mustard about 30 yr ago and the control group includes 30 healthy persons. For all subjects complete blood counts and ARMSpolymerase chain reaction for JAK2 (V617F) mutation was carried out. Data were analyzed by statistical software using independent sample t-testand Mann- Whitney U test.

Results: JAK2 (V617F) mutation was detected, neither in the sulfur mustardveterans nor in the control group.  Moreover no significant difference was detected in hematologic parameters between the two groups.

Conclusion: Despite sulfur mustard can increase risk of tumor genesis especially hematologic neoplasms but this is probablyas result of other genetic mechanism apart from JAK2 mutation. Considering the health and importance of preventive measure for the sulfur mustard victims, we suggest other genetic aspects of tumor genesis to be assessed in these patients.

Keywords: Hematologic, Iran, JAK2, Mutation, Sulfur Mustard
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Type of Study: Research | Subject: Special
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