[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 11, Number 1 (January-Fabruary 2017) ::
IJT 2017, 11(1): 43-47 Back to browse issues page
Effects of Maternal Alpha Methyldopa Administration on Memory of Rat Offspring during Growing Age
Sara Molla Ali Akbari, Mohammad Rabbani, Mohammad Sharifzadeh, Ali Hosseini-Sharifabad *
Department of Pharmacology and Toxicology, Isfahan University of Medical Sciences, Isfahan, Iran. , hosseini_a@pharm.mui.ac.ir
Abstract:   (385 Views)

Background: Alpha Methyldopa (AMD) is a well-known treatment for the pregnancy induced hypertension and commonly used in several countries. Indeed the possible effect of AMD on the behavioral activities of offspring, whom are exposed during fetus period, has not been studied. The present study evaluated the possible effect of maternal administration of AMD on the rat offspring memory in the growing age.

Methods: This study was carried out in Isfahan Faculty Of Pharmacy in 2015. Pregnant wistar rats were injected 400 mg/kg AMD or saline every day from 14th to 21st pregnancy period, respective to their group (n=8). The spatial memory of male offspring (n=9) was evaluated one, two and three month after the birth in the object recognition task. Also two groups of adult animals (n=7) were daily administered 400 mg/kg AMD or saline one week prior to the memory evaluation. The discrimination (d2), recognition (R) and frequencies of exploration of new object (FB) in the T2 trials are used as the memory indicating factors.

Results: Daily single dose of 400 mg/kg AMD to the mothers one week prior to the delivery significantly decreased the d2 index, R index and FB in two and three months offspring rats compare to the their respective control groups.

Conclusion: The newborn rats exposed maternally to the AMD during the fetus period show cognitive impairments in the growing age. Indeed the rate of memory enhancement follows a slow pattern compare to the control offspring rats.

Keywords: Alpha Methyldopa, Memory, Pregnancy, Offspring, Rat.
Full-Text [PDF 234 kb]   (306 Downloads)    
Type of Study: Research | Subject: Special
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Molla Ali Akbari S, Rabbani M, Sharifzadeh M, Hosseini-Sharifabad A. Effects of Maternal Alpha Methyldopa Administration on Memory of Rat Offspring during Growing Age. IJT. 2017; 11 (1) :43-47
URL: http://ijt.arakmu.ac.ir/article-1-528-en.html
Volume 11, Number 1 (January-Fabruary 2017) Back to browse issues page
مجله سم شناسی و مسمومیتهای ایران Iranian Journal of Toxicology
Persian site map - English site map - Created in 0.047 seconds with 791 queries by yektaweb 3461