Write your message
Volume 11, Issue 1 (January-Fabruary 2017)                   IJT 2017, 11(1): 11-17 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Aladodo R A, Balogun E A, Sunmonu T O, Nurain I O. Combinatorial Effects of Aqueous Root Extract of Jatropha Curcas and J. Gossypiifolia in Alloxan-Induced Diabetic Rats. IJT 2017; 11 (1) :11-17
URL: http://ijt.arakmu.ac.ir/article-1-544-en.html
1- Department of Biosciences and Biotechnology, Kwara State University, Malete, Ilorin, Nigeria , raliat.aladodo@kwasu.edu.ng
2- Department of Biochemistry, University of Ilorin, Ilorin, Nigeria
3- Department of Biological Sciences, Al-Hikma University, Ilorin, Nigeria
4- Department of Biosciences and Biotechnology, Kwara State University, Malete, Ilorin, Nigeria
Abstract:   (4697 Views)

Background: Combinatorial effects of aqueous root extract of Jatropha curcas (Jc) and J. gossypiifolia (Jg) in alloxan-induced diabetic rats was investigated in this research.

Methods: Thirty-six wistar rats were randomized into six groups of six animals each. Group I (control) was not induced but received 0.5 ml of distilled water. Groups II, III, IV, V and VI were induced with diabetes mellitus using alloxan monohydrate and received 14.2 mg/kg body weight (b/wt) glucophage, 0.5ml of distilled water, 250 mg/kg body weight of the root extracts of J. curcas, J. gossypiifolia and the combined extract respectively for 15 d.

Results: The mixture of J. curcas and J. gossypiifolia in alloxan-induced diabetic rats resulted in significant reduction in the blood glucose between 39.7% reduction by day 3 and 73.3% reduction by day 13 (P<0.05). The abnormal levels of serum and liver enzymes in the diabetic group reflected the significant alteration of liver function by alloxan monohydrate and administration of the mixture was found to restore each enzyme activity to a level that compared well with glucophage. The serum lipid levels were also restored to near normal by this mixture for all the evaluated parameters.

Conclusion: The mixture of roots of J. curcas and J. gossypiifolia has a greater potential for effective antidiabetic activity compare with individual plant extracts and may be safe for consumption.

Full-Text [PDF 592 kb]   (1343 Downloads)    
Type of Study: Research | Subject: General

References
1. Wills RB, Bone K, Morgan M. Herbal products: active constituents, modes of action and quality control. Nutr Res Rev 2000;13(01):47-77. [DOI:10.1079/095442200108729007]
2. Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol 2002;81(1):81-100. [DOI:10.1016/S0378-8741(02)00059-4]
3. Chen X-W, B Sneed KB, Pan S-Y, Cao C, R Kanwar J, Chew H, et al. Herb-drug interactions and mechanistic and clinical considerations. Curr Drug Metab 2012;13(5):640-51. [DOI:10.2174/1389200211209050640]
4. Okigbo R, Anuagasi C, Amadi J. Advances in selected medicinal and aromatic plants indigenous to Africa. J Med Plant Res 2009;3(2):086-95.
5. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Practice 2010;87(1):4-14. [DOI:10.1016/j.diabres.2009.10.007]
6. Boyle JP, Engelgau MM, Thompson TJ, Goldschmid MG, Beckles GL, Timberlake DS, et al. Estimating prevalence of type 1 and type 2 diabetes in a population of African Americans with diabetes mellitus. Am J Epidemiol 1999;149(1):55-63. [DOI:10.1093/oxfordjournals.aje.a009728]
7. Attele AS, Zhou YP, Xie JT. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 2002;51(6):1851-58. [DOI:10.2337/diabetes.51.6.1851]
8. Aladodo RA, Muhammad NO, Balogun EA. Effects of Aqueous Root Extract of Jatropha curcas on Hyperglycaemic and Haematological Indices in Alloxan-induced Diabetic Rats. Fountain J Natural Appl Sci 2013;2(1): 52-8.
9. Singh H, Sharma S. Antidiabetic activity of Jatropha gossypifolia Linn root extracts in alloxan induced diabetic mice. Int Res J Pharm. 2013;4:210-2. [DOI:10.7897/2230-8407.04543]
10. Chenni A, Yahia DA, Boukortt F, Prost J, Lacaille-Dubois M, Bouchenak M. Effect of aqueous extract of Ajuga iva supplementation on plasma lipid profile and tissue antioxidant status in rats fed a high-cholesterol diet. J Ethnopharmacol 2007;109(2):207-13. [DOI:10.1016/j.jep.2006.05.036]
11. Alwan A. Global status report on noncommunicable diseases 2010: World Health Organization; 2011.
12. Abolfathi AA, Mohajeri D, Rezaie A, Nazeri M. Protective effects of green tea extract against hepatic tissue injury in streptozotocin-induced diabetic rats. J Evidence-Based Complementary Altern Med 2012;2012.
13. Seino S, Takahashi H, Takahashi T, Shibasaki T. Treating diabetes today: a matter of selectivity of sulphonylureas. Diabetes Obes Metab 2012;14(s1):9-13. [DOI:10.1111/j.1463-1326.2011.01507.x]
14. Atawodi SE. Evaluation of the Hypoglycemic, Hypolipidemic and Antioxidant Effects of Methanolic Extract of" Ata-Ofa" Polyherbal Tea (A Polyherbal) in Alloxan-Induced Diabetic Rats. Drug Invent Today 2011;3(11).
15. Snow V, Aronson MD, Hornbake ER, Mottur-Pilson C, Weiss KB. Lipid control in the management of type 2 diabetes mellitus: a clinical practice guideline from the American College of Physicians. Ann Intern Med 2004;140(8):644-9. [DOI:10.7326/0003-4819-140-8-200404200-00012]
16. O'Brien RM, Granner DK. Regulation of gene expression by insulin. Biochem J 1991;278(Pt 3):609. [DOI:10.1042/bj2780609]
17. Malomo S. Toxicological implications of ceftriaxone administration in rats. Proteins. 2000;5:34-8.
18. Akanji MA. A comparative biochemical study of the interaction of some trypanocides with rat tissue cellular system. D Thesis University of Ife, Ile-Ife. 1986.
19. Wright PJ, Plummer DT. The use of urinary enzyme measurements to detect renal damage caused by nephrotoxic compounds. Biochem Pharmacol 1974;23(1):65-73. [DOI:10.1016/0006-2952(74)90314-1]
20. Malbica J, Hart L. Effect of adenosine triphosphate and some anti-inflammatory agents on a purified lysosomal fraction having high acid phosphatase and labile β-glucuronidase activity. Biochem Pharmacol 1971;20(8):2017-26. [DOI:10.1016/0006-2952(71)90401-1]
21. Colev V, Bădescu M, Păduraru I, Mândreci I, Bohotin C. [The zinc-metabolic disorder relation in experimental diabetes mellitus. Rom J Intern Med 1993;32(1):71-5.

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Iranian Journal of Toxicology

Designed & Developed by : Yektaweb