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:: Volume 11, Issue 3 (May-June 2017) ::
IJT 2017, 11(3): 19-26 Back to browse issues page
Histological and Functional Alteration in the Liver and Kidney and the Response of Antioxidants in Japanese quail Exposed to Dietary Cadmium
Omid Karimi , Saeed Hesaraki * , Seyyed Pejman Mortazavi
Department of Pathology, Science and Research Branch, Islamic Azad University, Tehran, Iran , hesarakisaeed@yahoo.com
Abstract:   (1293 Views)

Background: The aim of the present study was to find the effects of cadmium (Cd) on Japanese quail on the role of an animal model in order to understand the toxicity of Cd in creatures presented, within the environment.

Methods: One hundred 30-day-old male Japanese quails were equally divided into the control group and Cd group. The control group received no Cd while the Cd group was given formula feed comprised of 100 ppm of Cd (CdCl2, Merck, Germany) for sixty days. The histological and functional alteration in the liver and kidneys and the response of antioxidants were determined.

Results: Histological changes in the liver increased the number of kuppfer cells, vacuolar degeneration, and hepatocytes single cell necrosis in the Cd group. The renal histopathological changes were hyaline cast in renal tubules and necrosis and swelling of tubular epithelial cells. The level of aminotransferases (ALT and AST), blood urea nitrogen (BUN) and creatinine rose significantly in the Cd group toward the control group (P<0.05). The antioxidants (SOD, CAT and GSH) levels considerably diminished, while lipid peroxidation proliferated substantially in the hepatic and renal tissues of Japanese quails in the CD group (P<0.05).

Conclusion: Presentation to dietary Cd (100mg/kg diet) for 60 reduces the body weights gain and induces the histological and functional alteration in the liver and kidneys of Japanese quail as well as cellular antioxidant alterations.

Keywords: Antioxidant, Cadmium, Function, Histology, Japanese Quail
Full-Text [PDF 366 kb]   (1124 Downloads)    
Type of Study: Research | Subject: Special
Acceptance letter [JPG 3825 KB]  (51 Download)
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Karimi O, Hesaraki S, Mortazavi S P. Histological and Functional Alteration in the Liver and Kidney and the Response of Antioxidants in Japanese quail Exposed to Dietary Cadmium. IJT. 2017; 11 (3) :19-26
URL: http://ijt.arakmu.ac.ir/article-1-551-en.html


Volume 11, Issue 3 (May-June 2017) Back to browse issues page
مجله سم شناسی و مسمومیتهای ایران Iranian Journal of Toxicology
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