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:: Volume 12, Issue 3 (May-June 2018) ::
IJT 2018, 12(3): 29-37 Back to browse issues page
Antimalarial and Reno-protective Potentials of Combined Stem Bark Extracts of Khaya grandifoliola and Enantia chlorantha in Plasmodium Infected Mice
Ismaila Olanrewaju Nurain , Clement Olatunbosun Bewaji , Abdulazeez Aderemi Abubakar , Abdulrazaq Mustapha , Emmanuel Oladipo Ajani , Saeed Sabiu , Lutfat Abimbola Usman , Hassan Taye Abdulhameed , Sikiru Bolaji Ahmed
Department of Biochemistry, School of Basic Medical Science, College of Pure and Applied Sciences, Kwara State University, Ilorin, Nigeria. , ismaila4u2@yahoo.com
Abstract:   (303 Views)
Background: Malaria is a worldwide threat, which affects millions of people. Although several antimalarial has been reported, they are either not effective or toxic. This study evaluated the antimalarial efficacy and safety of stem bark aqueous extracts of Khaya grandifoliola (KG) and Enantia chlorantha (EC) in Plasmodium berghie (NK65S) infected Swiss mice.
Methods: Forty-two animals were grouped into six groups. Group A (control) comprised uninfected animals given sterile placebo. Group B was infected but untreated. Groups C, D, E, and F were infected and treated with 50 mg/kg artemisinin-based combination therapy (ACT), 400 mg/kg body weight of KG, EC, and the combined extracts (200 mg/ml body weight each) respectively.
Results: Alkaloids, terpenoids, glycosides, phenolics, flavonoids, tannin and saponins were all present in the two extracts. The percentage parasitemia in the treated groups C, D, E, and F was significantly (P˂0.05) reduced from 44%, 24%, 35%, and 31% to 17%, 8%, 9% and 8% respectively. The level of creatinine C (1.33±0.08 g/d), D (2.07±0.15 g/d), E (2.17±0.24 g/d) and F (1.20±0.0.12 g/d) increased significantly (P˂0.05) compared to group A (0.73±0.08 g/d). There was no significant difference in the urea level, potassium and sodium concentrations among all the groups.
Conclusion: The efficacy and renal safety of oral administration of aqueous stem bark extract of KG and EC were confirmed. Therefore, the extracts could be used as alternatives to standard drugs in the management of malaria.
Keywords: Combination Therapy, Enantia chlorantha, Khaya grandifoliola, Malaria, Reno Protective Effects
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Type of Study: Research | Subject: General
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Nurain I O, Bewaji C O, Abubakar A A, Mustapha A, Ajani E O, Sabiu S, et al . Antimalarial and Reno-protective Potentials of Combined Stem Bark Extracts of Khaya grandifoliola and Enantia chlorantha in Plasmodium Infected Mice. IJT. 2018; 12 (3) :29-37
URL: http://ijt.arakmu.ac.ir/article-1-659-en.html


Volume 12, Issue 3 (May-June 2018) Back to browse issues page
مجله سم شناسی و مسمومیتهای ایران Iranian Journal of Toxicology
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