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:: Volume 12, Issue 4 (July-August 2018) ::
IJT 2018, 12(4): 1-4 Back to browse issues page
Effect of Sulfur Mustard Toxicity on FLT3-ITD Gene Mutation in Sulfur Mustard Veterans
Hossein Ayatollahi , Ali Asgharzadeh , Mohammad Rafiee , Mohammad Reza Keramati , Mohyedin Barzegar , Vahid Amiri , Mahdi Balali-Mood , Mohammad-Hadi Sadeghian
Anatomo Clinical Pathologist, Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. , keramatimr@mums.ac.ir
Abstract:   (219 Views)
Background: Sulfur mustard (SM) is a chemical blistering warfare that affects different organs especially hematopoietic system. Prevalence of acute myeloblastic and lymphoblastic leukemia is increased by sulfur mustard exposure. FLT3-ITD mutation can be effective on leukemogenesis. Therefore, the aim of this study was to verify the frequency of FLT3-ITD mutation in the patients who exposed to SM.
Methods: This study was implemented on 42 people poisoned by SM during Iraq-Iran war about three decades ago and is now resident in Mashhad, Iran. The control group included 30 healthy males that are relatives of the patients with first-degree. After DNA extraction, PCR was performed for FLT3-ITD analysis.
Results: By analysis of PCR products, no FLT3-ITD mutation was detected in the patient or control groups. There was no significant difference in hematological factors between the two groups.
Conclusion: Other mechanisms can lead to leukemia in SM exposed persons. Elapsed time after exposure to sulfur mustard can be effective on leukemogenesis, then future more study may be beneficial for early diagnosis of leukemia in SM exposed veterans.
Keywords: FLT3, Iran, Leukemia, Mutation, Sulfur Mustard
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Type of Study: Research | Subject: General
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Ayatollahi H, Asgharzadeh A, Rafiee M, Keramati M R, Barzegar M, Amiri V, et al . Effect of Sulfur Mustard Toxicity on FLT3-ITD Gene Mutation in Sulfur Mustard Veterans. IJT. 2018; 12 (4) :1-4
URL: http://ijt.arakmu.ac.ir/article-1-686-en.html


Volume 12, Issue 4 (July-August 2018) Back to browse issues page
مجله سم شناسی و مسمومیتهای ایران Iranian Journal of Toxicology
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