Write your message
Volume 14, Issue 2 (May 2020)                   IJT 2020, 14(2): 105-110 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Keshavarz Alikhani H, Zargan J, Bidmeshkipour A, Haji Nour Mohammadi A, Hosseinpour M, Heydari A et al . Antibacterial Activity of the Iranian Scorpion’s Crude Venom (Odontobuthus bidentatus) on Gram-positive and Gram-negative Bacteria. IJT 2020; 14 (2) :105-110
URL: http://ijt.arakmu.ac.ir/article-1-787-en.html
1- Department of Biology, Faculty of Basic Sciences, Razi University, Kermanshah, Iran.
2- Department of Biology, Faculty of Basic Sciences, Imam Hossein University, Tehran, Iran. , jazrgan@ihu.ac.ir
3- Department of Biology, Faculty of Basic Sciences, Imam Hossein University, Tehran, Iran.
4- Department of Agronomy and Plant Breeding, Faculty of Agriculture, Zanjan University, Zanjan, Iran.
Abstract:   (3110 Views)
Background: The venoms of some scorpions are rich in bioactive components that may be used in the development and discovery of new antibacterial drugs. The venoms have many components, such as neurotoxins, salts, proteins and peptides with therapeutic properties, and can rapidly eliminate a broad range of bacteria. This study evaluated the anti-bacterial activity of Odontobuthus bidentatus’ crude venom against typical Gram-positive and negative bacteria, such as Staphylococcus aureus, Bacillus subtilis, and Escherichia coli.
Methods: The antibacterial effects of the crude venom were evaluated using Minimal Inhibitory Concentration (MIC) and MTT assays and its IC50 value was determined, using GraphPad software. 
Results: The crude venom significantly inhibited the growth of both Gram-positive and negative bacteria. Also the MTT results showed that the crude venom significantly reduced the viability of E. Coli, S. Aureus, and B. Subtilis bacteria compared with that for the controls. The IC50 values of the venom for E.coli, S.aureus, and B.subtilis were 30.19, 17.64, and 24.13 µM, respectively. 
Conclusion: The findings suggest that the venom of O. bidentatus scorpion has antibacterial properties. Also, our results offer preliminary clues toward the development of new antibacterial agents and new drugs with high therapeutic potentials for use in animals and humans.
Full-Text [PDF 606 kb]   (929 Downloads) |   |   Full-Text (HTML)  (872 Views)  
Type of Study: Research | Subject: General

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Iranian Journal of Toxicology

Designed & Developed by : Yektaweb