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Volume 14, Issue 2 (Spring_In Press 2020)                   IJT 2020, 14(2): 4-4 | Back to browse issues page

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Tsado A N, Jigam A A, Akanya H O, Ossamulu I F, Ariyeloye S D. Acute Toxicity Studies and Anti-plasmodial Potentials of Newbouldia laevis and Crateva adansonii in Plasmodium Berghei-infected Mice. IJT. 2020; 14 (2) :4-4
URL: http://ijt.arakmu.ac.ir/article-1-803-en.html
1- Department of Basic and Applied Sciences, Niger State Polytechnic P.M.B. 01, Zungeru Nigeria, Department of Biochemistry, School of Life Sciences, Federal University of Technology, P.M.B. 65, Minna, Niger State, Nigeria.
2- Department of Biochemistry, School of Life Sciences, Federal University of Technology, P.M.B. 65, Minna, Niger State, Nigeria.
3- Department of Biochemistry, Institute of Health Sciences, Anadolu University, Eskisehir, Turkey. , ariyeloye@gmail.com
Abstract:   (75 Views)
Background: Newbouldia laevis and Crateva adansonii are popular plants used traditionally in the management of patients with malaria infection in Nigeria. In this study, the acute toxicity and anti-plasmodial effects of the leaf extracts of Newbouldia laevis and Crateva adansonii were investigated in mice.
Methods: The Anti-plasmodial activities of both extracts were investigated individually and combined in mice infected with the chloroquine sensitive ANKA-65 Plasmodium berghei strain. Five groups of four mice each were used in our experiments. The LD50 was determined, using the line equation of the mortality against dose levels plot.
Results: The extracts of N. laevis and C. adansonii had a safety level of 200mg/kg (LD50 = 471.43mg/kg) and 600mg/kg (LD50 = 3,500mg/kg), respectively. Each experimental group was infected with P. berghei strain. The percent inhibition of parasitemia induced by the extracts of N. laevis and C. adansonii were 30.14 ± 2.88% and 61.35 ± 1.41%, respectively, compared to the 78.89% achieved for the standard drug (chloroquine). Mice treated with the combined extracts had a parasite inhibition of 24.23 ± 0.86%. Upon the analysis of the extracts, there were tannins, steroids, flavonoids, saponins and alkaloids in both. The quantitative analyses revealed that tannins were the most abundant (261.85±4.76mg/100g & 92.71±6.58mg/100g) while saponins were the least abundant (15.09±1.13mg/100g & 14.08±1.28mg/100g) phytochemicals in both extracts.
Conclusions: The findings support the notion that the traditional use of either plant in the management of malaria in Nigeria appears to be logical.
     
Type of Study: Research | Subject: General

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