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Volume 15, Issue 3 (July 2021)
IJT 2021, 15(3): 175-194 |
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Addoum B, El khalfi B, Idiken M, Sakoui S, Derdak R, Aniq Filali O, et al . Synthesis, Characterization of Pyrano-[2,3-c]-Pyrazoles Derivatives and Determination of Their Antioxidant Activities. IJT 2021; 15 (3) :175-194
URL: http://ijt.arakmu.ac.ir/article-1-959-en.html
URL: http://ijt.arakmu.ac.ir/article-1-959-en.html
Boutaina Addoum * 
1, Bouchra El khalfi2 , Mohamed Idiken2 , Souraya Sakoui2 , Reda Derdak2 , Ouafaa Aniq Filali2 , Abdelhakim Elmakssoudi3 , Abdelaziz Soukri2
1, Bouchra El khalfi2 , Mohamed Idiken2 , Souraya Sakoui2 , Reda Derdak2 , Ouafaa Aniq Filali2 , Abdelhakim Elmakssoudi3 , Abdelaziz Soukri2
1- Department of Biology, Laboratory of Physiopathology, Genetics, Molecular and Biotechnology (PGMB), Faculty of Sciences Aïn Chock, Research Center of Health and Biotechnology, Hassan II University of Casablanca, Casablanca, Morocco. , addoum636@gmail.com
2- Department of Biology, Laboratory of Physiopathology, Genetics, Molecular and Biotechnology (PGMB), Faculty of Sciences Aïn Chock, Research Center of Health and Biotechnology, Hassan II University of Casablanca, Casablanca, Morocco.
3- Department of Chemistry, Laboratory of Organic Synthesis, Extraction, and Valorization, Faculty of Sciences Aïn Chock, Hassan II University of Casablanca, Casablanca, Morocco.
2- Department of Biology, Laboratory of Physiopathology, Genetics, Molecular and Biotechnology (PGMB), Faculty of Sciences Aïn Chock, Research Center of Health and Biotechnology, Hassan II University of Casablanca, Casablanca, Morocco.
3- Department of Chemistry, Laboratory of Organic Synthesis, Extraction, and Valorization, Faculty of Sciences Aïn Chock, Hassan II University of Casablanca, Casablanca, Morocco.
Abstract: (2413 Views)
Background: Antioxidants are developed to assist the immune system and overcome oxidative stress, the aggression of cellular constituents due to imbalance between reactive oxygen species and the inner antioxidant system. The main objective of this study was to search for new and potent antioxidants to protect humans against diseases associated with oxidative stress.
Methods: In this study, three pyrano-[2,3-c]-pyrazole derivatives were synthesized via Multicomponent Reaction (MCR) approach and were characterized, using a melting point, High-Performance Liquid Chromatography (HPLC), and spectroscopic analyses (IR; 1H-NMR; 13C-NMR). All of the generated compounds were screened for their antioxidant properties in vivo, using ciliate “Tetrahymena” as a model organism exposed to oxidative and nitrative stress. They were then studied in vitro by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assays.
Results: The results demonstrated that the three compounds (5a, b, c) are biologically active and possess potent antioxidant activities, especially the 5a and 5b derivatives. On the other hand, the in vitro bioassays revealed that the 5a derivative possessed a significant antioxidant activity much greater than ascorbic acid. Accordingly, the in silico data are consistent with the experimental data.
Conclusion: These findings confirmed the potent antioxidant property of the synthesized compounds, providing us with new inspiration and challenges to design a library of pharmaceutical compounds with strong activity and low toxicity in the future.
Methods: In this study, three pyrano-[2,3-c]-pyrazole derivatives were synthesized via Multicomponent Reaction (MCR) approach and were characterized, using a melting point, High-Performance Liquid Chromatography (HPLC), and spectroscopic analyses (IR; 1H-NMR; 13C-NMR). All of the generated compounds were screened for their antioxidant properties in vivo, using ciliate “Tetrahymena” as a model organism exposed to oxidative and nitrative stress. They were then studied in vitro by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assays.
Results: The results demonstrated that the three compounds (5a, b, c) are biologically active and possess potent antioxidant activities, especially the 5a and 5b derivatives. On the other hand, the in vitro bioassays revealed that the 5a derivative possessed a significant antioxidant activity much greater than ascorbic acid. Accordingly, the in silico data are consistent with the experimental data.
Conclusion: These findings confirmed the potent antioxidant property of the synthesized compounds, providing us with new inspiration and challenges to design a library of pharmaceutical compounds with strong activity and low toxicity in the future.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
