Effect of betaine against hepatotoxicity and nephrotoxicity associated with acrylamide in rats

Fasahi, Javad; Baghshani, Hasan; Moosavi, Zahra

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Volume 19, Issue 4 (October 2025) IJT 2025, 19(4): 0-0 | Back to browse issues page

Ethics code: IR.UM.REC.1400.018

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Fasahi J, Baghshani H, Moosavi Z. Effect of betaine against hepatotoxicity and nephrotoxicity associated with acrylamide in rats. IJT 2025; 19 (4)
URL: http://ijt.arakmu.ac.ir/article-1-1417-en.html

Effect of betaine against hepatotoxicity and nephrotoxicity associated with acrylamide in rats

Javad Fasahi¹

, Hasan Baghshani ^*²

, Zahra Moosavi³

1- Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
2- Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran , baghishani@um.ac.ir
3- Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran

Abstract: (38 Views)

This study aimed to examine betaine effects against acrylamide-induced damage in the liver and kidney of rats. 28 male rats were divided into four groups. The first group served as control. The second group received acrylamide (50 mg/kg body weight; i.p.) during the experiment (11 days). Group 3 received betaine (2% in the diet) and acrylamide. Rats of group 4 received betaine (2% in the diet). Plasma ALT, AST, urea, creatinine, and bilirubin values increased significantly in group 2 compared to the control. Betaine treatment in group 3 significantly decreased ALT values relative to group 2. Hepatic GPx, SOD, CAT and GSH as well as renal GPx, SOD, FRAP, and GSH values showed significant decline in group 2 relative to the controls. Values of hepatic and renal GPx, SOD, CAT, FRAP and GSH in group 3 notably increased to the levels that were comparable with those of the control group. Additionally, a significant ascending trend of tissue protein carbonyls and MDA levels was found in group 2, while betaine treatment in third group decreased these indices to the levels that were comparable with controls. Moreover, acrylamide-induced histopathological features including significant increase of hepatic hyperemia and necrosis and renal necrosis, hyperemia, and cell swelling were attenuated by betaine treatment in group 3. These findings indicate that betaine can mitigate acrylamide-induced hepatotoxicity and nephrotoxicity which might be related to betaine’s antioxidant and methyl donor potential.

Keywords: Acrylamide, Betaine, Antioxidant, Kidney, Liver.

Type of Study: Research | Subject: Special

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