Write your message
Volume 9, Issue 30 (Autumn 2015)                   IJT 2015, 9(30): 1402-1406 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Yousofvand N, Fahim M. Effects of Chronic Exposure to Sodium Arsenate on Kidney of Rats. IJT 2015; 9 (30) :1402-1406
URL: http://ijt.arakmu.ac.ir/article-1-458-en.html
1- Department of Biology, University of Razi, Kermanshah, Iran. , yousofvand@razi.ac.ir
2- Department of Physiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
Abstract:   (4122 Views)
Background: In the present study, histopathological effects of chronic exposure to sodium arsenate in drinkable water were studied on a quantity of organs of rat.
Methods: Rats were divided into two groups, group I served as control group, were main-tained on deionized drinkable water for 2 months, and group II the study group were given 60 g/ml of sodium arsenate in deionized drinkable water for 2 months. Blood and urine samples from two groups of animals were collected under anesthesia and the animals were sacrificed under deep anesthesia (a-chloralose, 100 mg/kg, I.P). Their kidney, liver, aorta, and heart were dissected out and cleaned of surrounding connective tissue. The organs were kept in formaldehyde (10%) for histopathologic examination. Serum and urine samples from two groups were collected and analyzed for arsenic level. Total quantity of arsenic in serum and urine of animal was measured through graphic furnace atomic absorption spectrometry (GF-AAS).
 Results: Examination with light microscopy did not show any visible structural changes in the aorta, myocardium, and liver of chronic arsenic treated animals.However, a significant effect was observed in the kidneys of chronic arsenic treated rats showing distinct changes in proxi-mal tubular cells. There was high concentration of arsenic in serum and urine of arsenic ex-posed animals (group II) significantly (P<0.001).
 Conclusion: Swollen tubular cells in histopathologic study of kidney may suggest toxic effects of arsenic in the body.
Full-Text [PDF 2895 kb]   (1871 Downloads)    
Type of Study: Research | Subject: General

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2023 CC BY-NC 4.0 | Iranian Journal of Toxicology

Designed & Developed by : Yektaweb