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Volume 20, Issue 1 (January 2026)
IJT 2026, 20(1): 35-41 |
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Ethics code: (ERCANA/2023/12/001)
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Akingbade M, Ekpe Asuquo E, Oluwafemi Faeji C, Olaniran O, Akinwande Fasoro A. Morphological and Molecular Assessment of Quercetin’s Protective Role Against Aspirin-induced Testicular Damage in Male Wistar Rats. IJT 2026; 20 (1) :35-41
URL: http://ijt.arakmu.ac.ir/article-1-1528-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1528-en.html
Modupe Akingbade1 
, Ekpe Ekpe Asuquo2 , Charles Oluwafemi Faeji *3 , Olabode Olaniran4 , Ayo Akinwande Fasoro5
, Ekpe Ekpe Asuquo2 , Charles Oluwafemi Faeji *3 , Olabode Olaniran4 , Ayo Akinwande Fasoro5
1- Department of Anatomy, Ekiti State University, Ado Ekiti, Nigeria.
2- Department of Science, College of West Anglia, King's Lynn, England.
3- Department of Science, College of West Anglia, King's Lynn, England. ,charles.faeji@cwa.ac.uk
4- Independent Researcher, Leeds, England.
5- Department of Public Health, University of Otago, Wellington, New Zealand.
2- Department of Science, College of West Anglia, King's Lynn, England.
3- Department of Science, College of West Anglia, King's Lynn, England. ,
4- Independent Researcher, Leeds, England.
5- Department of Public Health, University of Otago, Wellington, New Zealand.
Abstract: (167 Views)
Background: About 10-15% of couples experience infertility, which is a serious health issue, with 40% of cases being attributed to male partners. Studies have reported that aspirin can induce reproductive toxicity, hence leading to infertility. Quercetin is a natural product and dietary supplement that has been utilized for its antioxidant and anti-inflammatory properties. It is crucial to find an antioxidant that can enhance fertility and mitigate the harmful effects on male fertility. This study aimed to assess the morphological and molecular effects of quercetin on aspirin-induced testicular damage in Wistar rats.
Methods: Thirty-five adult male Wistar rats weighing 150-200 g were divided into seven groups. Olive oil and normal saline were administered to the two control groups. Aspirin (50 mg/kg/day), quercetin (30 mg/kg/day or 60 mg/kg/day), or a combination of aspirin and quercetin was administered to the remaining groups. The study lasted for 30 days, and assessments were conducted through morphological and molecular evaluations.
Results: It was found that animals in the control (normal saline), olive oil, and quercetin groups showed no significant increase in gross anatomical parameters or histomorphology but underwent an increase in body weight, indicating an active growth phase. Quercetin treatment improved the sperm count, motility, and morphology of aspirin-induced groups, which also had some molecular and histomorphology alterations.
Conclusion: Potential of Quercetin as a medicinal substance can substantially improve aspirin-induced testicular toxicity.
Methods: Thirty-five adult male Wistar rats weighing 150-200 g were divided into seven groups. Olive oil and normal saline were administered to the two control groups. Aspirin (50 mg/kg/day), quercetin (30 mg/kg/day or 60 mg/kg/day), or a combination of aspirin and quercetin was administered to the remaining groups. The study lasted for 30 days, and assessments were conducted through morphological and molecular evaluations.
Results: It was found that animals in the control (normal saline), olive oil, and quercetin groups showed no significant increase in gross anatomical parameters or histomorphology but underwent an increase in body weight, indicating an active growth phase. Quercetin treatment improved the sperm count, motility, and morphology of aspirin-induced groups, which also had some molecular and histomorphology alterations.
Conclusion: Potential of Quercetin as a medicinal substance can substantially improve aspirin-induced testicular toxicity.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
