Enter your email address
Submit
Write your message
Volume 19, Issue 2 (April 2025)
IJT 2025, 19(2): 0-0 |
Back to browse issues page
Ethics code: 03-1864/4
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Babulovska A, Petkovska L, Pereska Z, Simonovska N, Berat Huseini A, Kostadinoski K et al . Rhabdomyolysis and High-Sensitivity Troponin I activity in acutely intoxicated patients. IJT 2025; 19 (2)
URL: http://ijt.arakmu.ac.ir/article-1-1448-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1448-en.html
Aleksandra Babulovska *1 
, Lidija Petkovska2 , Zhanina Pereska2 , Natasha Simonovska3 , Afrodita Berat Huseini2 , Kristin Kostadinoski2 , Kiril Naumoski2
, Lidija Petkovska2 , Zhanina Pereska2 , Natasha Simonovska3 , Afrodita Berat Huseini2 , Kristin Kostadinoski2 , Kiril Naumoski2
1- University Clinic for Toxicology, 1000 Skopje, Republic of North Macedonia, Faculty of Medicine, Ss. Cyril and Methodius, University in Skopje, 1000 Skopje, Republic of North Macedonia , ababulovska@yahoo.com
2- University Clinic for Toxicology, 1000 Skopje, Republic of North Macedonia, Faculty of Medicine, Ss. Cyril and Methodius, University in Skopje, 1000 Skopje, Republic of North Macedonia
3- : University Clinic for Toxicology, 1000 Skopje, Republic of North Macedonia, Faculty of Medicine, Ss. Cyril and Methodius, University in Skopje, 1000 Skopje, Republic of North Macedonia
2- University Clinic for Toxicology, 1000 Skopje, Republic of North Macedonia, Faculty of Medicine, Ss. Cyril and Methodius, University in Skopje, 1000 Skopje, Republic of North Macedonia
3- : University Clinic for Toxicology, 1000 Skopje, Republic of North Macedonia, Faculty of Medicine, Ss. Cyril and Methodius, University in Skopje, 1000 Skopje, Republic of North Macedonia
Abstract: (85 Views)
Objectives: This study evaluated the high-sensitivity Troponin I activity in patients with rhabdomyolysis following acute intoxication with either psychotropic drugs or other chemical agents.
Methods: This study randomly recruited 140 patients suffering from rhabdomyolysis. They were divided into two groups affected by either psychotropic drugs or chemical agents. High-sensitivity troponin (hsTnI) was measured in all patients with rhabdomyolysis three times, during the first, third, and fifth days of hospitalization.
Results: The mean high-sensitivity Troponin I value on the first, third, and fifth days was 27.7 ± 78.3 µg / L, vs. 43.7 ± 135.9 µg / L, vs. 28.73 ± 57.01g / L. The third day of hospitalization in all patients hs-TnI was significantly higher than the fifth day. According to the intoxication agent on the first day, we determined the highest values of hs-TnI in methadone intoxications (N = 5) - 279.7 ± 190.7 µg / L, other drugs (N = 1) - 138.4 µg / L; benzodiazepines (N = 3) - 213.9 ± 232.5 µg / L. Analysis by type of intoxication on the first, third, and fifth days showed that hs-TnI values were insignificantly higher in the psychotropic group compared with the chemical group.
Conclusion: Clinicians should be aware of the possibility of increasing high-sensitivity Troponin I in patients with rhabdomyolysis due to acute intoxication. Elevated levels of hs–TnI in psychotropic intoxications were likely related to specific etiologies such as illicit substance use. In contrast, chemical intoxication was associated with the clinical outcome of intoxication.
Methods: This study randomly recruited 140 patients suffering from rhabdomyolysis. They were divided into two groups affected by either psychotropic drugs or chemical agents. High-sensitivity troponin (hsTnI) was measured in all patients with rhabdomyolysis three times, during the first, third, and fifth days of hospitalization.
Results: The mean high-sensitivity Troponin I value on the first, third, and fifth days was 27.7 ± 78.3 µg / L, vs. 43.7 ± 135.9 µg / L, vs. 28.73 ± 57.01g / L. The third day of hospitalization in all patients hs-TnI was significantly higher than the fifth day. According to the intoxication agent on the first day, we determined the highest values of hs-TnI in methadone intoxications (N = 5) - 279.7 ± 190.7 µg / L, other drugs (N = 1) - 138.4 µg / L; benzodiazepines (N = 3) - 213.9 ± 232.5 µg / L. Analysis by type of intoxication on the first, third, and fifth days showed that hs-TnI values were insignificantly higher in the psychotropic group compared with the chemical group.
Conclusion: Clinicians should be aware of the possibility of increasing high-sensitivity Troponin I in patients with rhabdomyolysis due to acute intoxication. Elevated levels of hs–TnI in psychotropic intoxications were likely related to specific etiologies such as illicit substance use. In contrast, chemical intoxication was associated with the clinical outcome of intoxication.
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
