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Volume 19, Issue 2 (April 2025)
IJT 2025, 19(2): 107-111 |
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Ethics code: 03-1864/4
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Babulovska A, Petkovska L, Pereska Z, Simonovska N, Berat Huseini A, Kostadinoski K et al . Rhabdomyolysis and High-Sensitivity Troponin I activity in acutely intoxicated patients. IJT 2025; 19 (2) :107-111
URL: http://ijt.arakmu.ac.ir/article-1-1448-en.html
URL: http://ijt.arakmu.ac.ir/article-1-1448-en.html
Aleksandra Babulovska *1 
, Lidija Petkovska2 , Zhanina Pereska2 , Natasha Simonovska3 , Afrodita Berat Huseini2 , Kristin Kostadinoski2 , Kiril Naumoski2
, Lidija Petkovska2 , Zhanina Pereska2 , Natasha Simonovska3 , Afrodita Berat Huseini2 , Kristin Kostadinoski2 , Kiril Naumoski2
1- University Clinic for Toxicology, 1000 Skopje, Republic of North Macedonia, Faculty of Medicine, Ss. Cyril and Methodius, University in Skopje, 1000 Skopje, Republic of North Macedonia , ababulovska@yahoo.com
2- University Clinic for Toxicology, 1000 Skopje, Republic of North Macedonia, Faculty of Medicine, Ss. Cyril and Methodius, University in Skopje, 1000 Skopje, Republic of North Macedonia
3- : University Clinic for Toxicology, 1000 Skopje, Republic of North Macedonia, Faculty of Medicine, Ss. Cyril and Methodius, University in Skopje, 1000 Skopje, Republic of North Macedonia
2- University Clinic for Toxicology, 1000 Skopje, Republic of North Macedonia, Faculty of Medicine, Ss. Cyril and Methodius, University in Skopje, 1000 Skopje, Republic of North Macedonia
3- : University Clinic for Toxicology, 1000 Skopje, Republic of North Macedonia, Faculty of Medicine, Ss. Cyril and Methodius, University in Skopje, 1000 Skopje, Republic of North Macedonia
Abstract: (226 Views)
Background: This study evaluated the high-sensitivity Troponin I (hs-TnI) activity in patients with rhabdomyolysis following acute intoxication with either psychotropic drugs or other chemical agents.
Methods: This study randomly recruited 140 patients suffering from rhabdomyolysis. They were divided into two groups affected by either psychotropic drugs or chemical agents. hs-TnI was measured in all patients with rhabdomyolysis three times (i.e., the first, third, and fifth days of hospitalization).
Results: The mean hs-TnI values on the first, third, and fifth days were obtained at 27.7±78.3 µg/L, 43.7±135.9 µg/L, and 28.73±57.01g/L, respectively. On the third day of hospitalization, hs-TnI was significantly higher in all patients, compared to the fifth day. According to the intoxication agent on the first day, the highest values of hs-TnI were determined in methadone intoxications (N = 5) - 279.7 ± 190.7 µg / L, benzodiazepines (N = 3) - 213.9 ± 232.5 µg / L, other drugs (N = 1) - 138.4 µg / L. Analysis by the type of intoxication on the first, third, and fifth days showed that hs-TnI values were insignificantly higher in the psychotropic group, compared to the chemical group.
Conclusion: Clinicians should be aware of the possibility of increasing hs-TnI in patients with rhabdomyolysis due to acute intoxication. Elevated levels of hs-TnI in psychotropic intoxications were likely related to the specific etiologies, such as illicit substance use, while chemical intoxication was associated with the clinical outcome of intoxication.
Methods: This study randomly recruited 140 patients suffering from rhabdomyolysis. They were divided into two groups affected by either psychotropic drugs or chemical agents. hs-TnI was measured in all patients with rhabdomyolysis three times (i.e., the first, third, and fifth days of hospitalization).
Results: The mean hs-TnI values on the first, third, and fifth days were obtained at 27.7±78.3 µg/L, 43.7±135.9 µg/L, and 28.73±57.01g/L, respectively. On the third day of hospitalization, hs-TnI was significantly higher in all patients, compared to the fifth day. According to the intoxication agent on the first day, the highest values of hs-TnI were determined in methadone intoxications (N = 5) - 279.7 ± 190.7 µg / L, benzodiazepines (N = 3) - 213.9 ± 232.5 µg / L, other drugs (N = 1) - 138.4 µg / L. Analysis by the type of intoxication on the first, third, and fifth days showed that hs-TnI values were insignificantly higher in the psychotropic group, compared to the chemical group.
Conclusion: Clinicians should be aware of the possibility of increasing hs-TnI in patients with rhabdomyolysis due to acute intoxication. Elevated levels of hs-TnI in psychotropic intoxications were likely related to the specific etiologies, such as illicit substance use, while chemical intoxication was associated with the clinical outcome of intoxication.
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The Iranian Journal of Toxicology
Arak University of Medical Sciences in collaboration with the Iranian Society of Toxicology
Website: http://ijt.arakmu.ac.ir
Email: tox.journal@gmail.com
