[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 12, Issue 2 (March-April 2018) ::
IJT 2018, 12(2): 15-20 Back to browse issues page
In Vivo Assessment of Gamma Rays, Electron-beam Irradiation plus a Commercial Toxin Binder (Milbond-TX) As an Anti-Aflatoxin B1 in a Chicken Model
Saeed Hasanpour , Shaban Rahimi , Omid Fani Makki , Gholamreza Shahhosseini , Alireza Khosravi
MSc of Poultry Science, Research and Development Office, Zarin Gostar Sarina Company, Kashmar, Iran. , ofanimakki@birjand.ac.ir
Abstract:   (550 Views)
Background: Aspergillus flavus is the most important fungus for production of Aflatoxin B1 (AFB1). This study evaluated the ability of gamma rays (GRs) and electron-beam irradiation (EBI) to counteract the deleterious effects of aflatoxin B1 (AFB1) in a chicken model.
Methods: Overall, 168 one-day-old male Coturnix quails were assigned to eight treatments for 42 d in Tehran, Iran, in 2010 and 2011. Two dietary inclusion rates of AFB1 (0 and 2 ppm) and toxin binders, such as 0, 27 kGy doses of GRs, 27 kGy doses of EBI, and 0.3% of commercial toxin binder-milbond-TX, were tested in a 2×4 factorial manner. Serum biochemical parameters, immune response, and dietary treatments on factors associated with kidney and lipid profiles were determined on day 42.
Results: AFB1 significantly decreased the hematological parameters (Hematocrit in 21 and 42 d), immune response (White blood cell (WBC), heterophil to lymphocyte ratio (H/L) and sheep red blood cell (SRBC)), and blood chemical factors (glucose, albumin, total protein, and triglycerides) compared to the control diet (P<0.05). It also significantly increased the calcium, phosphorus, uric acid, and low-density lipoprotein (LDL) levels (P<0.05). The addition of toxin binders, such as GRs, EBI, and milbond-TX, in the contaminated diets significantly diminished the inhibitory effects of dietary AFB1 (P<0.05) on the hematological parameters, immune response, blood chemical factors, and factors associated with kidney and lipids profile with no differences compared to the control diet.
Conclusion: The addition of these toxin binders may reduce the adverse effects produced by the presence of AFB1 in Japanese quails’ diets.
Keywords: Aflatoxin B1, Electron-Beam Irradiation, Gamma Rays, Japanese Quail, Milbond-TX
Full-Text [PDF 936 kb]   (212 Downloads)    
Type of Study: Research | Subject: General
References
1. Amiridumari H, Sarir H, Afzali N, FaniMakki O. Effects of milk thistle seed against aflatoxin B1 in broiler model. J Res Med 2013;18(9):786-90.
2. Amiri Dumari M, Sarir H, Fani Makki O, Afzali N. Effect of Milk Thistle (Silybum marianum L.) on Biochemical Parameters and Immunity of Broiler Chicks Fed Aflatoxin B1 after Three Weeks. Iran J Toxicol 2014;8(26):1098-103.
3. Yunus AW, Razzazi-Fazeli E, Bohm J. Aflatoxin B1 in affecting broiler's performance, immunity, and gastrointestinal tract: A review of history and contemporary issues. Toxins 2011;3(6):566-90. [DOI:10.3390/toxins3060566]
4. Do JH, Choi D-K. Aflatoxins: detection, toxicity, and biosynthesis. Biotechnol Bioprocess Eng 2007;12(6):585-93. [DOI:10.1007/BF02931073]
5. Dohnal V, Wu Q, Kuča K. Metabolism of aflatoxins: key enzymes and interindividual as well as interspecies differences. Arch toxicol 2014;88(9):1635-44. [DOI:10.1007/s00204-014-1312-9]
6. Di Stefano V, Pitonzo R, Cicero N, D'Oca MC. Mycotoxin contamination of animal feedingstuff: detoxification by gamma-irradiation and reduction of aflatoxins and ochratoxin A concentrations. Food Addit Contam, Part A 2014;31(12):2034-9. [DOI:10.1080/19440049.2014.968882]
7. Fernandes Â, Barreira JC, Antonio AL, Oliveira MBP, Martins A, Ferreira IC. Feasibility of electron-beam irradiation to preserve wild dried mushrooms: Effects on chemical composition and antioxidant activity. Innovative Food Sci Emerging Technol 2014;22:158-66. [DOI:10.1016/j.ifset.2013.12.015]
8. Javanmard M, Rokni N, Bokaie S, Shahhosseini G. Effects of gamma irradiation and frozen storage on microbial, chemical and sensory quality of chicken meat in Iran. Food control 2006;17(6):469-73. [DOI:10.1016/j.foodcont.2005.02.008]
9. CNR. Nutrient requirements of poultry. Washington DC National Academic Press 1994;42:57-63.
10. Onofri A. DSAASTAT a new Excel VBA macro to perform basic statistical analyses of field trials. Department of Agriculture and Environmental Sciences, University of Perugia, Italy. 2010.
11. Sharma M, Singh R, Mandal A, Kurade N. Amelioration of aflatoxicosis by methionine supplementation in broiler chickens. Indian J Poult Sci 2014;49(1):1-6.
12. Manafi M, Hedayati M, Yari M. Aflatoxicosis and Herbal Detoxification: The Effectiveness of Thyme Essence on Performance Parameters and Antibody Titers of Commercial Broilers Fed Aflatoxin B 1. Res Protozool 2014;4(2):43-50.
13. Bagherzadeh Kasmani F, Karimi Torshizi M, Allameh A, Shariatmadari F. A novel aflatoxin-binding Bacillus probiotic: Performance, serum biochemistry, and immunological parameters in Japanese quail. Poult Sci 2012;91(8):1846-53. [DOI:10.3382/ps.2011-01830]
14. Ul-Hassan Z, Zargham Khan M, Khan A, Javed I. Immunological status of the progeny of breeder hens kept on ochratoxin A (OTA)-and aflatoxin B1 (AFB1)-contaminated feeds. J Immunotoxicol 2012;9(4):381-91. [DOI:10.3109/1547691X.2012.675365]
15. Goldblatt L. Aflatoxin: scientific background, control, and implications: Elsevier; 2012.
16. Peng X, Zhang K, Bai S, Ding X, Zeng Q, Yang J, et al. Histological lesions, cell cycle arrest, apoptosis and T cell subsets changes of spleen in chicken fed aflatoxin-contaminated corn. Int J Environ Res Public Health 2014;11(8):8567-80. [DOI:10.3390/ijerph110808567]
17. Calado T, Venâncio A, Abrunhosa L. Irradiation for mold and mycotoxin control: A review. Compr Rev Food Sci Food Saf 2014;13(5):1049-61. [DOI:10.1111/1541-4337.12095]
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hasanpour S, Rahimi S, Fani Makki O, Shahhosseini G, Khosravi A. In Vivo Assessment of Gamma Rays, Electron-beam Irradiation plus a Commercial Toxin Binder (Milbond-TX) As an Anti-Aflatoxin B1 in a Chicken Model. IJT. 2018; 12 (2) :15-20
URL: http://ijt.arakmu.ac.ir/article-1-650-en.html


Volume 12, Issue 2 (March-April 2018) Back to browse issues page
مجله سم شناسی و مسمومیتهای ایران Iranian Journal of Toxicology
Persian site map - English site map - Created in 0.08 seconds with 31 queries by YEKTAWEB 3755